BDBM50545414 CHEMBL1852155

SMILES Cc1ccc(cc1)S(=O)(=O)N1CCCN(Cc2ccccc2)CCCN(CC(=C)C1)S(=O)(=O)c1ccc(C)cc1

InChI Key InChIKey=SRJIECKMPIRMJJ-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50545414   

TargetSortilin(Human)
University of Nevada

Curated by ChEMBL
LigandPNGBDBM50545414(CHEMBL1852155)
Affinity DataIC50: 380nMAssay Description:Inhibition of GFP-tagged Sortilin (unknown origin) expressed in HEK293T cells after 42 hrs by FACS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetT-cell surface glycoprotein CD4(Human)
University of Nevada

Curated by ChEMBL
LigandPNGBDBM50545414(CHEMBL1852155)
Affinity DataIC50: 210nMAssay Description:Inhibition of FITC-tagged human CD4 expressed in human SUP-T1 cells after 72 hrs by FACS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetT-cell surface glycoprotein CD4(Human)
University of Nevada

Curated by ChEMBL
LigandPNGBDBM50545414(CHEMBL1852155)
Affinity DataIC50: 330nMAssay Description:Binding affinity to signal peptide of human CD4-YFP expressed in CHO-K1 cells assessed down-modulation of CD4 surface expression incubated for 24 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed