BDBM50544696 CHEMBL4642922

SMILES Clc1ccc(CNC(=O)[C@@H]2CCC(=O)N2c2cccs2)c(Cl)c1

InChI Key InChIKey=PCHSDJRKGJKOAG-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50544696   

TargetP2X purinoceptor 7(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50544696(CHEMBL4642922)
Affinity DataIC50: 720nMAssay Description:Displacement of [3H]-A804598 from human P2X7 expressed in human HEK293 cell membrane incubated for 1 hr by microplate scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50544696(CHEMBL4642922)
Affinity DataIC50: 229nMAssay Description:Inhibition of human P2X7 expressed in human HEK293 cells assessed as reduction in BzATP-stimulated TO-PRO-3 incorporation preincubated with compound ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
University of Lille

Curated by ChEMBL
LigandPNGBDBM50544696(CHEMBL4642922)
Affinity DataKi:  147nMAssay Description:Displacement of [3H]-A804598 from human P2X7 expressed in human HEK293 cell membrane incubated for 1 hr by microplate scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2021
Entry Details Article
PubMed