BDBM50544424 CHEMBL4632655::US11192850, Entry 4d

SMILES COC(=O)c1cc(C#Cc2ccc(NC(=O)C(O)=O)cc2)c(cc1O)N(C)C

InChI Key InChIKey=LFCKZQCWXJBSRF-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50544424   

TargetTYR_PHOSPHATASE_2 domain-containing protein(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50544424(CHEMBL4632655 | US11192850, Entry 4d)
Affinity DataIC50: 30nMAssay Description:Inhibition of Mycobacterium tuberculosis PTPB expressed in Escherichia coli BL21 (DE3) using p-nitrophenyl phosphate as substrate measured after 30 m...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50544424(CHEMBL4632655 | US11192850, Entry 4d)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of SHP2 (unknown origin) expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate measured after 30 mins by UV-vis sp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50544424(CHEMBL4632655 | US11192850, Entry 4d)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of PTP1B (unknown origin) expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate measured after 30 mins by UV-vis s...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50544424(CHEMBL4632655 | US11192850, Entry 4d)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of SHP1 (unknown origin) expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate measured after 30 mins by UV-vis sp...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTriple specificity protein phosphatase PtpB(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Purdue Research Foundation

US Patent
LigandPNGBDBM50544424(CHEMBL4632655 | US11192850, Entry 4d)
Affinity DataIC50: 30nMAssay Description:Compounds were tested against mPTPB using the p-nitrophenyl phosphate (pNPP) assay system in a Cary 100 UV-Vis spectrophotometer by monitoring the in...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50544424(CHEMBL4632655 | US11192850, Entry 4d)
Affinity DataIC50: 5.00E+4nMAssay Description:Compounds were tested against mPTPB using the p-nitrophenyl phosphate (pNPP) assay system in a Cary 100 UV-Vis spectrophotometer by monitoring the in...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50544424(CHEMBL4632655 | US11192850, Entry 4d)
Affinity DataIC50: 5.00E+4nMAssay Description:Compounds were tested against mPTPB using the p-nitrophenyl phosphate (pNPP) assay system in a Cary 100 UV-Vis spectrophotometer by monitoring the in...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50544424(CHEMBL4632655 | US11192850, Entry 4d)
Affinity DataIC50: 5.00E+4nMAssay Description:Compounds were tested against mPTPB using the p-nitrophenyl phosphate (pNPP) assay system in a Cary 100 UV-Vis spectrophotometer by monitoring the in...More data for this Ligand-Target Pair
In DepthDetails
US Patent