BDBM50544420 CHEMBL4635310::US11192850, Entry 4

SMILES OC(=O)C(=O)Nc1ccc(cc1)C#Cc1ccccc1

InChI Key InChIKey=GILWTVLGHCFELD-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50544420   

TargetTYR_PHOSPHATASE_2 domain-containing protein(Mycobacterium tuberculosis (strain CDC 1551 / Oshk...)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50544420(CHEMBL4635310 | US11192850, Entry 4)
Affinity DataIC50: 257nMAssay Description:Inhibition of Mycobacterium tuberculosis PTPB expressed in Escherichia coli BL21 (DE3) using p-nitrophenyl phosphate as substrate measured after 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50544420(CHEMBL4635310 | US11192850, Entry 4)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of SHP2 (unknown origin) expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate measured after 30 mins by UV-vis sp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50544420(CHEMBL4635310 | US11192850, Entry 4)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PTP1B (unknown origin) expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate measured after 30 mins by UV-vis s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50544420(CHEMBL4635310 | US11192850, Entry 4)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of SHP1 (unknown origin) expressed in Escherichia coli BL21 using p-nitrophenyl phosphate as substrate measured after 30 mins by UV-vis sp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTriple specificity protein phosphatase PtpB(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Purdue Research Foundation

US Patent
LigandPNGBDBM50544420(CHEMBL4635310 | US11192850, Entry 4)
Affinity DataIC50: 257nMAssay Description:Compounds were tested against mPTPB using the p-nitrophenyl phosphate (pNPP) assay system in a Cary 100 UV-Vis spectrophotometer by monitoring the in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2022
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50544420(CHEMBL4635310 | US11192850, Entry 4)
Affinity DataIC50: 1.00E+5nMAssay Description:Compounds were tested against mPTPB using the p-nitrophenyl phosphate (pNPP) assay system in a Cary 100 UV-Vis spectrophotometer by monitoring the in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2022
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50544420(CHEMBL4635310 | US11192850, Entry 4)
Affinity DataIC50: 1.00E+5nMAssay Description:Compounds were tested against mPTPB using the p-nitrophenyl phosphate (pNPP) assay system in a Cary 100 UV-Vis spectrophotometer by monitoring the in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2022
Entry Details
Go to US Patent

TargetTriple specificity protein phosphatase PtpB(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Purdue Research Foundation

US Patent
LigandPNGBDBM50544420(CHEMBL4635310 | US11192850, Entry 4)
Affinity DataIC50: 257nMAssay Description:Compounds were tested against mPTPB using the p-nitrophenyl phosphate (pNPP) assay system in a Cary 100 UV-Vis spectrophotometer by monitoring the in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2022
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50544420(CHEMBL4635310 | US11192850, Entry 4)
Affinity DataIC50: 1.00E+5nMAssay Description:Compounds were tested against mPTPB using the p-nitrophenyl phosphate (pNPP) assay system in a Cary 100 UV-Vis spectrophotometer by monitoring the in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2022
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 6(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50544420(CHEMBL4635310 | US11192850, Entry 4)
Affinity DataIC50: 1.00E+5nMAssay Description:Compounds were tested against mPTPB using the p-nitrophenyl phosphate (pNPP) assay system in a Cary 100 UV-Vis spectrophotometer by monitoring the in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2022
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50544420(CHEMBL4635310 | US11192850, Entry 4)
Affinity DataIC50: 1.00E+5nMAssay Description:Compounds were tested against mPTPB using the p-nitrophenyl phosphate (pNPP) assay system in a Cary 100 UV-Vis spectrophotometer by monitoring the in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/17/2022
Entry Details
Go to US Patent