BDBM50541811 CHEMBL4637336

SMILES C[C@H]1CN(CCN1C(c1ccc(F)cc1)c1ccc(F)cc1)c1c(Cl)c(=O)n(C)c2ccc(nc12)C#N

InChI Key InChIKey=UFIZEEXQYAMFJQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50541811   

TargetDiacylglycerol kinase alpha(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM50541811(CHEMBL4637336)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of full-length C-terminal His6 tagged TVMV-pFBgate fused human DGKalpha expressed in baculovirus infected Sf9 insect cells using liposome ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetDiacylglycerol kinase zeta(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM50541811(CHEMBL4637336)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of full length C-terminal His6tagged TVMV-His-pFBgate fused human DGK-zeta expressed in baculovirus infected Sf9 insect cells using liposo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetDiacylglycerol kinase zeta(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM50541811(CHEMBL4637336)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of DGKA/DGKZ in human CD8 cells assessed as induction of CD8 activation by measuring IFNgamma level after 20 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetDiacylglycerol kinase zeta(Human)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM50541811(CHEMBL4637336)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of DGKalpha/zeta in human whole blood assessed as induction of T-cell activation by measuring IFNgamma level preincubated for 1 hr followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed