BDBM50541717 CHEMBL4646640::US11926614, Example 5

SMILES Clc1ccccc1-n1c(nnc1-c1ccncn1)[C@H]1C[C@@H](C1)NC(=O)c1ccnc2cccnc12

InChI Key InChIKey=ARDLHSGXMZNXNJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50541717   

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Oslo

Curated by ChEMBL
LigandPNGBDBM50541717(CHEMBL4646640 | US11926614, Example 5)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human TNKS2 (873 to 1162 residues) measured after 20 hrs in presence of NAD+ by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Human)
University of Oslo

Curated by ChEMBL
LigandPNGBDBM50541717(CHEMBL4646640 | US11926614, Example 5)
Affinity DataIC50: 0.0480nMAssay Description:Inhibition of TNKS1/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by dual-glo lucifer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Oslo

Curated by ChEMBL
LigandPNGBDBM50541717(CHEMBL4646640 | US11926614, Example 5)
Affinity DataIC50: 0.850nMAssay Description:Biochemical IC50 values for the following compounds were determined in accordance with the following protocol (see also Anumala et al., Discovery of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/23/2024
Entry Details
Go to US Patent