BDBM50541715 CHEMBL4633567

SMILES Clc1ccccc1-n1c(nnc1C12CC(C1)(C2)n1c2ccc(cc2[nH]c1=O)C#N)-c1ccncn1

InChI Key InChIKey=KEKRVUGHUCXWSM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50541715   

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Oslo

Curated by ChEMBL
LigandPNGBDBM50541715(CHEMBL4633567)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of human TNKS2 (873 to 1162 residues) measured after 20 hrs in presence of NAD+ by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Human)
University of Oslo

Curated by ChEMBL
LigandPNGBDBM50541715(CHEMBL4633567)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of TNKS1/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by dual-glo lucifer...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed