BDBM50541710 CHEMBL4640597::US11926614, Example 181

SMILES FC(F)Oc1ccc(nc1)-c1nnc([C@H]2C[C@@H](C2)NC(=O)c2ccc(F)cn2)n1-c1ccccc1F

InChI Key InChIKey=HIXCMHOBVDTAIE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50541710   

TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Oslo

Curated by ChEMBL
LigandPNGBDBM50541710(CHEMBL4640597 | US11926614, Example 181)
Affinity DataIC50: 7.40nMAssay Description:Inhibition of human TNKS2 (873 to 1162 residues) measured after 20 hrs in presence of NAD+ by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Human)
University of Oslo

Curated by ChEMBL
LigandPNGBDBM50541710(CHEMBL4640597 | US11926614, Example 181)
Affinity DataIC50: 27nMAssay Description:Inhibition of TNKS1/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by dual-glo lucifer...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
University of Oslo

Curated by ChEMBL
LigandPNGBDBM50541710(CHEMBL4640597 | US11926614, Example 181)
Affinity DataIC50: 7.40nMAssay Description:Biochemical IC50 values for the following compounds were determined in accordance with the following protocol (see also Anumala et al., Discovery of ...More data for this Ligand-Target Pair
In DepthDetails
US Patent