BDBM50541598 CHEMBL4645565

SMILES CC(O)(C#Cc1ccc(N2CCOCC2)c(Nc2ncnc3[nH]ccc23)c1)c1nccs1

InChI Key InChIKey=KJMURTHIPWRIMC-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50541598   

TargetMitogen-activated protein kinase kinase kinase 14(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50541598(CHEMBL4645565)
Affinity DataIC50: 9.90nMAssay Description:Inhibition of recombinant N-terminal GST-fused human NIK (319 to 947 residues) expressed in baculovirus expression system incubated for 120 mins in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 14(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50541598(CHEMBL4645565)
Affinity DataIC50: 9.70nMAssay Description:Inhibition of human NIK using myelin basic protein as substrate in presence of [gamma33P]ATP by hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetAurora kinase B(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50541598(CHEMBL4645565)
Affinity DataIC50: 43nMAssay Description:Inhibition of human Aurora B using [H-LRRASLG] as substrate in presence of [gamma33P]ATP by hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetNT-3 growth factor receptor(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50541598(CHEMBL4645565)
Affinity DataIC50: 50nMAssay Description:Inhibition of human TRKC using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma33P]ATP by hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50541598(CHEMBL4645565)
Affinity DataIC50: 95nMAssay Description:Inhibition of human LRRK2 using [RLGRDKYKTLRQIRQ] as substrate in presence of [gamma33P]ATP by hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50541598(CHEMBL4645565)
Affinity DataIC50: 192nMAssay Description:Inhibition of human ACK1 using [EAIYAAPFAKKK] as substrate in presence of [gamma33P]ATP by hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50541598(CHEMBL4645565)
Affinity DataIC50: 183nMAssay Description:Inhibition of human JAK1 using poly[Glu:Tyr] (4:1) as substrate in presence of [gamma33P]ATP by hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50541598(CHEMBL4645565)
Affinity DataIC50: 892nMAssay Description:Inhibition of human JAK3 using [GGEEEEYFELVKKKK] as substrate in presence of [gamma33P]ATP by hotspot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed