BDBM50538438 CHEMBL4640297

SMILES Cc1ccc(cc1C#Cc1cnc2cccnn12)C(=O)Nc1ccc(CN2CCC3C=NNC3C2)c(Cl)c1

InChI Key InChIKey=PCSKFQHKWWNIKM-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50538438   

TargetMitogen-activated protein kinase kinase kinase kinase 3(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50538438(CHEMBL4640297)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of MAP4K3 (unknown origin) assessed as residual activity incubated for 5 mins in presence of [gamma-33ATP] by scintillation counting based...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetEphrin type-B receptor 3(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50538438(CHEMBL4640297)
Affinity DataIC50: 51nMAssay Description:Inhibition of EPHB3 (unknown origin) assessed as residual activity incubated for 5 mins in presence of [gamma-33ATP] by scintillation counting based ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetEphrin type-B receptor 2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50538438(CHEMBL4640297)
Affinity DataIC50: 93nMAssay Description:Inhibition of EPHB2 (unknown origin) assessed as residual activity incubated for 5 mins in presence of [gamma-33ATP] by scintillation counting based ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50538438(CHEMBL4640297)
Affinity DataIC50: 710nMAssay Description:Inhibition of SRC (unknown origin) assessed as residual activity incubated for 5 mins in presence of [gamma-33ATP] by scintillation counting based ra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50538438(CHEMBL4640297)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of PDGFRalpha (unknown origin) assessed as residual activity incubated for 5 mins in presence of [gamma-33ATP] by scintillation counting b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetDiscoidin domain-containing receptor 2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50538438(CHEMBL4640297)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of DDR2 (unknown origin) assessed as residual activity incubated for 5 mins in presence of [gamma-33ATP] by scintillation counting based r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50538438(CHEMBL4640297)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of ABL1 (unknown origin) assessed as residual activity incubated for 5 mins in presence of [gamma-33ATP] by scintillation counting based r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50538438(CHEMBL4640297)
Affinity DataIC50: 5.58E+3nMAssay Description:Inhibition of human recombinant CYP3A4 expressed in insect cell microsomes in presence of NADPH by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50538438(CHEMBL4640297)
Affinity DataIC50: 5.02E+3nMAssay Description:Inhibition of human ERG incubated for 4 hrs by competitive fluorescence tracer binding based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50538438(CHEMBL4640297)
Affinity DataIC50: 10nMAssay Description:Inhibition of human ABL1 assessed as residual activity using EAIYAAPFAKKK as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetEphrin type-B receptor 4(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50538438(CHEMBL4640297)
Affinity DataIC50: 138nMAssay Description:Inhibition of EPHB4 (unknown origin) assessed as residual activity incubated for 5 mins in presence of [gamma-33ATP] by scintillation counting based ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50538438(CHEMBL4640297)
Affinity DataIC50: 91nMAssay Description:Inhibition of LCK (unknown origin) assessed as residual activity incubated for 5 mins in presence of [gamma-33ATP] by scintillation counting based ra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Nek6(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50538438(CHEMBL4640297)
Affinity DataIC50: 3.31E+3nMAssay Description:Inhibition of NEK6 (unknown origin) assessed as residual activity incubated for 5 mins in presence of [gamma-33ATP] by scintillation counting based r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2021
Entry Details Article
PubMed