BDBM50536410 CHEMBL4561692

SMILES COc1ncc(cc1NS(C)(=O)=O)-c1cc2COCc2c(NC(=O)CN2CCOCC2)c1

InChI Key InChIKey=INNGAVFDQLSCJJ-UHFFFAOYSA-N

Data  32 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 50536410   

TargetSphingosine kinase 1(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SPHK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetPhosphatidylinositol 5-phosphate 4-kinase type-2 alpha(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PIP4K2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ASK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 251nMAssay Description:Inhibition of PI3Kdelta in human PBMC assessed as reduction in cytostim-induced IFNgamma production after 20 hrs by electrochemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PIK3C2B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of P38alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetDiacylglycerol kinase zeta(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of DAGK zeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCholine/ethanolamine kinase(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CHKB (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase beta(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PIK4B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 2.51E+3nMAssay Description:Inhibition of DNA-PK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDE4B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase alpha(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PIK4A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetPhosphatidylinositol 4-kinase type 2-alpha(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PI4K2A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IKK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetCholine kinase alpha(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of choline kinase alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of LRRK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ITK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 250nMAssay Description:Inhibition of PI3Kdelta in human PBMC assessed as reduction in cytostim-induced IFNgamma production after 20 hrs by electrochemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 158nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate preincubated for 15 mins followed by substrate addition measured after 60 mins in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetSphingosine kinase 2(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SPHK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FRAP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Glaxosmithkline R&D

Curated by ChEMBL
LigandPNGBDBM50536410(CHEMBL4561692)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IKK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMed