BDBM50535698 CHEMBL4533071

SMILES c1cc(c(cc1C(=O)Nc2cc(c(c(c2)F)F)F)S(=O)(=O)N3CCC(CC3)O)F

InChI Key InChIKey=KKMFSVNFPUPGCA-UHFFFAOYSA-N

Data  1 IC50  2 EC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50535698   

TargetCapsid protein(HBV)
Novira Therapeutics

Curated by ChEMBL
LigandPNGBDBM50535698(CHEMBL4533071)
Affinity DataEC50:  470nMAssay Description:Binding affinity to capsid protein in Hepatitis B virus infected in human HepG2.2.15 cells assessed as inhibition of HBV DNA replication incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCapsid protein(HBV)
Novira Therapeutics

Curated by ChEMBL
LigandPNGBDBM50535698(CHEMBL4533071)
Affinity DataEC50:  260nMAssay Description:Modulation of capsid assembly in HBV infected in human HePAD38 cells assessed as inhibition of viral DNA replication measured after 96 hrs by qPCR an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetCapsid protein(HBV)
Novira Therapeutics

Curated by ChEMBL
LigandPNGBDBM50535698(CHEMBL4533071)
Affinity DataIC50: 1.53E+3nMAssay Description:Inhibition of fluorescent-labeled capsid assembly in Hepatitis B virus incubated for 1 hr by fluorescence based analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2024
Entry Details
PubMedPDB3D3D Structure (crystal)