BDBM50533255 CHEMBL4476255

SMILES COc1cc(ccc1CN)C(=O)N1C[C@H](C[C@H]1C(=O)NCC(c1ccccc1)c1ccccc1)n1cc(nn1)C1CC1

InChI Key InChIKey=ZXPHIYQTYJUUQW-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50533255   

TargetChymotrypsinogen B2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533255(CHEMBL4476255)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human chymotrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533255(CHEMBL4476255)
Affinity DataIC50: 5.50E+4nMAssay Description:Inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533255(CHEMBL4476255)
Affinity DataIC50: 11nMAssay Description:Inhibition of human PRSS1 assessed as enzymatic cleavage of Benzoyl-GlyPro-Arg'Rh110-gammaGlu-OH by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533255(CHEMBL4476255)
Affinity DataIC50: 3.10E+4nMAssay Description:Inhibition of human f10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetChymotrypsinogen B2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533255(CHEMBL4476255)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human chymotrypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetNeutrophil elastase(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533255(CHEMBL4476255)
Affinity DataIC50: 5.50E+4nMAssay Description:Inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533255(CHEMBL4476255)
Affinity DataIC50: 11nMAssay Description:Inhibition of human PRSS1 assessed as enzymatic cleavage of Benzoyl-GlyPro-Arg'Rh110-gammaGlu-OH by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetProthrombin(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533255(CHEMBL4476255)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533255(CHEMBL4476255)
Affinity DataIC50: 2.40E+3nMAssay Description:Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cells measured after 90 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetProthrombin(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533255(CHEMBL4476255)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533255(CHEMBL4476255)
Affinity DataIC50: 2.40E+3nMAssay Description:Displacement of [3H]-dofetilide from human ERG expressed in HEK293 cells measured after 90 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50533255(CHEMBL4476255)
Affinity DataIC50: 3.10E+4nMAssay Description:Inhibition of human f10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed