BDBM50533248 CHEMBL4515745

SMILES COc1cccc2nc(C(=O)N(CCN(C)C)C3CS(=O)(=O)c4c3ccc(Cl)c4Cl)c(-c3ccc(F)c(C)c3)n12

InChI Key InChIKey=XZSVNSUXHLAOOA-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50533248   

TargetCentromere-associated protein E(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50533248(CHEMBL4515745)
Affinity DataEC50:  79nMAssay Description:Inhibition of CENP-E in human HeLa cells assessed as HH3 phosphorylated levels after 24 hrs by FACS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCentromere-associated protein E(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50533248(CHEMBL4515745)
Affinity DataEC50:  79nMAssay Description:Inhibition of CENP-E in human HeLa cells assessed as HH3 phosphorylated levels after 24 hrs by FACS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCentromere-associated protein E(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50533248(CHEMBL4515745)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human CENP-E motor domain assessed as ADP levels preincubated with protein motor domain/microtubule for 60 mins followed by ATP additio...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCentromere-associated protein E(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50533248(CHEMBL4515745)
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human CENP-E motor domain assessed as ADP levels preincubated with protein motor domain/microtubule for 60 mins followed by ATP additio...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed