BDBM50532342 CHEMBL4544378

SMILES CC(C)N(CCc1c[nH]c2ccccc12)Cc1ccc(NCCCCCNC(=O)\C=C\c2cccnc2)cc1

InChI Key InChIKey=GGNQLDGHZXOOSQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50532342   

TargetNicotinamide phosphoribosyltransferase(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50532342(CHEMBL4544378)
Affinity DataIC50: 25nMAssay Description:Inhibition of recombinant NAMPT (unknown origin) using nicotinamide as substrate measured every 5 mins for 30 mins in presence of recombinant NMNAT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50532342(CHEMBL4544378)
Affinity DataIC50: 25nMAssay Description:Inhibition of recombinant NAMPT (unknown origin) using nicotinamide as substrate measured every 5 mins for 30 mins in presence of recombinant NMNAT1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50532342(CHEMBL4544378)
Affinity DataIC50: 0.155nMAssay Description:Inhibition of NAMPT in human MCF7 cells assessed as decrease in NAD production after 24 hrs by NAD/NADH Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50532342(CHEMBL4544378)
Affinity DataIC50: 0.155nMAssay Description:Inhibition of NAMPT in human MCF7 cells assessed as decrease in NAD production after 24 hrs by NAD/NADH Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed