BDBM50532326 CHEMBL4519632

SMILES C/C=C/CN1C=C(c2cc[nH]c2C1=O)c3cccc(c3)C(=O)N(C)C

InChI Key InChIKey=RJEMCUZKQLRUIS-UHFFFAOYSA-N

Data  24 IC50

PDB links: 3 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50532326   

LigandPNGBDBM50532326(CHEMBL4519632)
Affinity DataIC50: 410nMAssay Description:Inhibition of recombinant His-tagged TAF1 isoform-2 (unknown origin) using biotinylated ligand incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50532326(CHEMBL4519632)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of biotinylated small-molecule ligand from recombinant His-tagged TAF1 bromodomain 1 (unknown origin) measured after 10 mins by TR-FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetPeregrin(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50532326(CHEMBL4519632)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of biotinylated small-molecule ligand from recombinant His-tagged BRPF1 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCREB-binding protein(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50532326(CHEMBL4519632)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of biotinylated small-molecule ligand from recombinant His-tagged CBP (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
LigandPNGBDBM50532326(CHEMBL4519632)
Affinity DataIC50: 5.70E+3nMAssay Description:Displacement of biotinylated small-molecule ligand from recombinant His-tagged TAF1 bromodomain 2 (unknown origin) measured after 10 mins by TR-FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetChromatin remodeling regulator CECR2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50532326(CHEMBL4519632)
Affinity DataIC50: 410nMAssay Description:Displacement of biotinylated small-molecule ligand from recombinant His-tagged CECR2 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50532326(CHEMBL4519632)
Affinity DataIC50: 1.40E+3nMAssay Description:Displacement of biotinylated small-molecule ligand from recombinant His-tagged BRD4 bromodomain 2 (unknown origin) measured after 10 mins by TR-FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50532326(CHEMBL4519632)
Affinity DataIC50: 460nMAssay Description:Displacement of biotinylated small-molecule ligand from recombinant His-tagged BRD4 bromodomain 1 (unknown origin) measured after 10 mins by TR-FRET ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 9(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50532326(CHEMBL4519632)
Affinity DataIC50: 160nMAssay Description:Displacement of biotinylated small-molecule ligand from recombinant His-tagged BRD9 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50532326(CHEMBL4519632)
Affinity DataIC50: 460nMAssay Description:Inhibition of recombinant His-tagged BRD4 bromodomain1 (unknown origin) using biotinylated ligand incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 9(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50532326(CHEMBL4519632)
Affinity DataIC50: 160nMAssay Description:Displacement of biotinylated JQ1 analog from recombinant His-tagged BRD9 (unknown origin) incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50532326(CHEMBL4519632)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant His-tagged TAF1 isoform-1 (unknown origin) using biotinylated ligand incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetChromatin remodeling regulator CECR2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50532326(CHEMBL4519632)
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of recombinant His-tagged CECR2 (unknown origin) using biotinylated ligand incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50532326(CHEMBL4519632)
Affinity DataIC50: 460nMAssay Description:Inhibition of recombinant His-tagged BRD4 bromodomain1 (unknown origin) using biotinylated ligand incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 9(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50532326(CHEMBL4519632)
Affinity DataIC50: 160nMAssay Description:Displacement of biotinylated JQ1 analog from recombinant His-tagged BRD9 (unknown origin) incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50532326(CHEMBL4519632)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant His-tagged TAF1 isoform-1 (unknown origin) using biotinylated ligand incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50532326(CHEMBL4519632)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of recombinant His-tagged BRD4 bromodomain2 (unknown origin) using biotinylated ligand incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCREB-binding protein(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50532326(CHEMBL4519632)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of biotinylated JQ1 analog from recombinant His-tagged CBP (unknown origin) incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetPeregrin(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50532326(CHEMBL4519632)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of biotinylated JQ1 analog from recombinant His-tagged BRPF1 (unknown origin) incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetChromatin remodeling regulator CECR2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50532326(CHEMBL4519632)
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of recombinant His-tagged CECR2 (unknown origin) using biotinylated ligand incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50532326(CHEMBL4519632)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of recombinant His-tagged BRD4 bromodomain2 (unknown origin) using biotinylated ligand incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCREB-binding protein(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50532326(CHEMBL4519632)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of biotinylated JQ1 analog from recombinant His-tagged CBP (unknown origin) incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetPeregrin(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50532326(CHEMBL4519632)
Affinity DataIC50: 2.00E+4nMAssay Description:Displacement of biotinylated JQ1 analog from recombinant His-tagged BRPF1 (unknown origin) incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50532326(CHEMBL4519632)
Affinity DataIC50: 410nMAssay Description:Inhibition of recombinant His-tagged TAF1 isoform-2 (unknown origin) using biotinylated ligand incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)