BDBM50532250 CHEMBL4444875

SMILES Cn1c(Nc2cc(CNC(=O)C3(CC3)C(F)(F)F)ccc2Cl)nc2cc(C(=O)NCC3CC3)c(OCC(F)F)cc12

InChI Key InChIKey=SLTBCEVHFGDXIP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50532250   

TargetProstaglandin E synthase(Human)
University Jena

Curated by ChEMBL
LigandPNGBDBM50532250(CHEMBL4444875)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of mPGES-1 in human A549 cells assessed as PGE2-alpha formation preincubated for 60 mins prior to IL-beta stimulation measured after 24 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
University Jena

Curated by ChEMBL
LigandPNGBDBM50532250(CHEMBL4444875)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of mPGES-1 in human A549 cells assessed as PGE2-alpha formation preincubated for 60 mins prior to IL-beta stimulation measured after 24 hr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
University Jena

Curated by ChEMBL
LigandPNGBDBM50532250(CHEMBL4444875)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human mPGES-1 expressed in CHO-K1 cells using PGH2 as substrate assessed as PGE2 formation preincubated for 20 mins followed by additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
University Jena

Curated by ChEMBL
LigandPNGBDBM50532250(CHEMBL4444875)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human mPGES-1 expressed in CHO-K1 cells using PGH2 as substrate assessed as PGE2 formation preincubated for 20 mins followed by additio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed