BDBM50532181 CHEMBL4474690

SMILES COc1cc(ccc1OCc1ccc(cc1)C1CC1)C1CN(C1)C(=O)c1cc(COC[C@@H](O)CO)ccn1

InChI Key InChIKey=LTTJGQBDGMNWHJ-UHFFFAOYSA-N

Data  52 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 52 hits for monomerid = 50532181   

Target3-phosphoinositide-dependent protein kinase 1(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human N-terminal His6-tagged PDK1 (52 to end residues) expressed in baculovirus infected Sf21 insect cells using PDKtide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human full-length N-terminal His6-tagged PKBalpha expressed in baculovirus infected Sf21 insect cells using Crosstide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetProtein kinase C beta type(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human N-terminal His6-tagged (2 to end residues) PKCbeta expressed in baculovirus infected Sf21 insect cells using Histone H1 as substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetProtein kinase C zeta type(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human PKCzetaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human full-length N-terminal GST-tagged SAPK2a expressed in baculovirus infected Sf21 insect cells using MBP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human N-terminal GST-tagged c-RAF Y340D/Y341D double mutant (306 to 648 residues) expressed in baculovirus infected Sf9 insect cells us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human N-terminal His6-tagged GSK3beta H350L mutant expressed in baculovirus infected Sf21 insect cells using phosphoglycogen synthase p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of full-length human N-terminal His6-tagged LCK expressed in baculovirus infected Sf21 insect cells using Src peptide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetProtein kinase C gamma type(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human full-length N-terminal His6-tagged PKCgamma expressed in baculovirus infected Sf21 insect cells using Histone H1 as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 261nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged TrkA (440 to end residues) expressed in baculovirus infected Sf21 insect cells using KKKSPGEYV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human N-terminal GST-tagged Flt3 (564 to end residues) expressed in baculovirus infected Sf21 insect cells using Abltide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human N-terminal His6-tagged PLK1 expressed in baculovirus infected Sf21 insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human full-length N-terminal GST-tagged/C-terminal His6-tagged MEK1 expressed in Escherichia coli using MBP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of full length human untagged PKAalpha expressed in Escherichia coli BL21 (DE3) pLysS cells using Kemptide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human full-length N-terminal His6-tagged PKCalpha expressed in baculovirus infected Sf21 insect cells using Histone H1 as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 11(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human full-length N-terminal GST-tagged SAPK2b2 expressed in baculovirus infected Sf21 insect cells using MBP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human full length N-terminal GST-tagged CHK1 expressed in baculovirus infected Sf21 insect cells using CHKtide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase CSK(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human full length N-terminal GST-tagged CSK expressed in Escherichia coli BL21 (DE3) cells using Poly (Glu4Tyr) as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human N-terminal GST-tagged Flt1 (783 to end residues) expressed in baculovirus infected Sf21 insect cells using KKKSPGEYVNIEFG as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of full-length human N-terminal His6-tagged IKKbeta expressed in baculovirus infected Sf21 insect cells using IKKtide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human N-terminal His-tagged KDR (790 to end residues) expressed in baculovirus infected Sf21 insect cells using myelin basic protein as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant full-length human N-terminal His6-tagged AuroraA expressed in baculovirus infected Sf21 insect cells using Kemptide as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human full-length N-terminal His-tagged p70S6K expressed in baculovirus infected Sf21 insect cells using CKRRRLASLR as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 12(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human full-length N-terminal GST-tagged SAPK3 expressed in Escherichia coli using MBP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase ZAP-70(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human full-length C-terminal His6-tagged ZAP70 expressed in baculovirus infected Sf21 insect cells using Poly (Glu4-Tyr) (4:1) as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Mouse)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 20nMAssay Description:Inhibition of CSF1R in CSF1-induced DBA/1J mouse BMMC assessed as reduction in LPS-induced IL6 production preincubated for overnight followed by LPS-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human full-length N-terminal His-tagged SRC expressed in baculovirus infected Sf9 insect cells using Poly-(Glu4:Tyr) as substrate measu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human N-terminal His6-tagged PDGFRalpha (550 to end residues) expressed in baculovirus infected Sf21 insect cells using Poly (Glu4-Tyr)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human N-terminal His6-tagged (11 to 552 residues) ROCK2 expressed in baculovirus infected Sf21 insect cells using Long S6 Kinase as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human full length C-terminal His6-tagged Cdk2/human full length N-terminal GST-tagged Cyclin A expressed in baculovirus infected Sf21 i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 3(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human N-terminal His6-tagged FGFR3 (447 to 761 residues) expressed in baculovirus infected Sf21 insect cells using Poly (Glu4-Tyr) (4:1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 14nMAssay Description:Inhibition of human CSF1R tyrosine kinase domain (538 to 972 residues) using Poly(Glu, Tyr)-biotinylated peptide as substrate preincubated for 5 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase Sgk1(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human N-terminal GST-tagged SGK1 (61 to 431 residues) expressed in baculovirus infected Sf21 insect cells Akt/SGK peptide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetLysine--tRNA ligase(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human N-terminal His6-tagged SYK expressed in baculovirus infected Sf21 insect cells using Poly (Glu4-Tyr) (4:1) as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human N-terminal His6-tagged TIE2 (771 to end residues) expressed in baculovirus infected Sf21 insect cells using Poly (Glu4-Tyr) (4:1)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged Abl (27 to end residues) expressed in baculovirus infected Sf21 insect cells using Abltide as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant full-length human N-terminal GST-tagged CDK1/cyclinB expressed in baculovirus infected Sf21 insect cells using Abltide as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human full length His6-tagged CK2alpha expressed in baculovirus infected Sf21 insect cells using Casein Kinase 2 substrate peptideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human N-terminal GST-tagged c-kit (544 to end residues) expressed in baculovirus infected Sf21 insect cells using Poly (Glu4-Tyr) (4:1)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of full-length human N-terminal His6-tagged JNK3 expressed in baculovirus infected Sf21 insect cells using ATF2 as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human N-terminal GST-tagged EGFR (696 to end residues) expressed in baculovirus infected Sf21 insect cells using Angiotensin II peptide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human N-terminal GST-tagged FGFR1 (456 to 765 residues) expressed in baculovirus infected Sf21 insect cells using IGF-IRtide (12-527) a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fyn(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human full-length N-terminal His6-tagged Fyn expressed in baculovirus infected Sf21 insect cells using Src peptide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human N-terminal His6-tagged IGF1R (959 to end residues) expressed in baculovirus infected Sf21 insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human N-terminal His6-tagged insulin receptor (1005 to 1310 residues) expressed in baculovirus infected Sf21 insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human N-terminal His-tagged JNK1alpha1 expressed in baculovirus infected Sf21 insect cells using ATF2 as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of full-length human N-terminal His-tagged JNK2alpha2 expressed in baculovirus infected Sf21 insect cells using ATF2 as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of full-length human N-terminal His6-tagged LYN expressed in baculovirus infected Sf21 insect cells using Poly (Glu4-Tyr) (4:1) as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 1(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human MAPK2 using myelin basic protein as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Japan Tobacco

Curated by ChEMBL
LigandPNGBDBM50532181(CHEMBL4474690)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human N-terminal His6-tagged MET (974 to end residues) expressed in baculovirus infected Sf21 insect cells using KKKSPGEYVNIEFG as subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
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