BDBM50532173 CHEMBL4536443::US20240139197, Compound 10

SMILES CCCCCCN(C)Cc1ccc(cc1)-c1[nH]c2c(cnn2c(=O)c1C(C)C)C#N

InChI Key InChIKey=HJWSLDFYCQJXLZ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50532173   

TargetLysine-specific demethylase 6B(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50532173(CHEMBL4536443 | US20240139197, Compound 10)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human C-terminal FLAG-tagged KDM6B (1043 to end residues) expressed in baculovirus infected Sf9 insect cells using H3(21-44)-K27(Me3)-G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetLysine-specific demethylase 5B(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50532173(CHEMBL4536443 | US20240139197, Compound 10)
Affinity DataIC50: 51nMAssay Description:Inhibition of human N-terminal FLAG/His-tagged KDM5B (2 to 751 residues) expressed in baculovirus infected Sf9 insect cells using H3(1-21)K4(Me3)-GGK...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50532173(CHEMBL4536443 | US20240139197, Compound 10)
Affinity DataIC50: 23nMAssay Description:Inhibition of human C-terminal FLAG-tagged KDM5A (1 to 1090 residues) expressed in baculovirus infected Sf9 insect cells using H3(1-21)K4(Me3)-GGK(Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetLysine-specific demethylase 2A(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50532173(CHEMBL4536443 | US20240139197, Compound 10)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human N-terminal FLAG/Avi-tagged KDM2A (2 to 700 residues) expressed in baculovirus infected Sf9 insect cells using H3(21-44)-K36(Me2)-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetLysine-specific demethylase 4A(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50532173(CHEMBL4536443 | US20240139197, Compound 10)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human N-terminal His-tagged KDM4A (1 to 350 residues) expressed in Escherichia coli using H3(21-44)-K36(Me3)-GK(Biotin)/2-OG as substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetLysine-specific demethylase 5C(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50532173(CHEMBL4536443 | US20240139197, Compound 10)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of full-length human N-terminal FLAG/His-tagged KDM5C (2 to 1560 residues) expressed in baculovirus infected Sf9 insect cells using H3(1-2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetHistone lysine demethylase PHF8(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50532173(CHEMBL4536443 | US20240139197, Compound 10)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human N-terminal FLAG-tagged KDM7B (2 to 525 residues) expressed in baculovirus infected Sf9 insect cells using H3(1-21)K9(Me2)-GGK(Bio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetLysine-specific demethylase 5A(Human)
Kyoto Prefectural University of Medicine

Curated by ChEMBL
LigandPNGBDBM50532173(CHEMBL4536443 | US20240139197, Compound 10)
Affinity DataIC50: 22.7nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2024
Entry Details
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