BDBM50530509 CHEMBL4556261::US11078188, Example 33

SMILES CC1N(C2CC2)c2cc(ccc2N(C)C1=O)-c1nc(nn1-c1ccc(C)cc1)C(=O)N1CCN(C)CC1

InChI Key InChIKey=LSTCQUNBWNVCHK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50530509   

TargetBromodomain-containing protein 4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50530509(CHEMBL4556261 | US11078188, Example 33)
Affinity DataIC50: 9.40nMAssay Description:Displacement of 5-FITC labelled (+)-JQ1 from His6-tagged human BRD4 bromodomain 1 expressed in Escherichia coli BL21(DE3) )-codon plus-RIL cells incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50530509(CHEMBL4556261 | US11078188, Example 33)
Affinity DataIC50: 9.40nMAssay Description:Displacement of 5-FITC labelled (+)-JQ1 from His6-tagged human BRD4 bromodomain 1 expressed in Escherichia coli BL21(DE3) )-codon plus-RIL cells incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50530509(CHEMBL4556261 | US11078188, Example 33)
Affinity DataIC50: 15.7nMAssay Description:Expression and purification of the BRD4(I) recognition domain: colonies of newly transformed plasmid DNA from E. coli BL21(DE3)-condon plus-RIL cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent