BDBM50530504 CHEMBL4537909::US11078188, Example 4

SMILES CC1N(C2CCCC2)c2cc(ccc2N(C)C1=O)-c1nnnn1-c1ccc(C)cc1

InChI Key InChIKey=WBDWZZQCGGSYBS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50530504   

TargetBromodomain-containing protein 4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50530504(CHEMBL4537909 | US11078188, Example 4)
Affinity DataIC50: 9.5nMAssay Description:Displacement of 5-FITC labelled (+)-JQ1 from His6-tagged human BRD4 bromodomain 1 expressed in Escherichia coli BL21(DE3) )-codon plus-RIL cells incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50530504(CHEMBL4537909 | US11078188, Example 4)
Affinity DataIC50: 9.5nMAssay Description:Displacement of 5-FITC labelled (+)-JQ1 from His6-tagged human BRD4 bromodomain 1 expressed in Escherichia coli BL21(DE3) )-codon plus-RIL cells incu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50530504(CHEMBL4537909 | US11078188, Example 4)
Affinity DataIC50: 18.4nMAssay Description:Expression and purification of the BRD4(I) recognition domain: colonies of newly transformed plasmid DNA from E. coli BL21(DE3)-condon plus-RIL cells...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent