BDBM50530394 CHEMBL4561663

SMILES NC(=O)c1ccccc1Nc1cc(Nc2ccc(F)cn2)ncc1C(N)=O

InChI Key InChIKey=HZNQENBILSFKNN-UHFFFAOYSA-N

Data  2 KI  23 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 50530394   

TargetJAK3/JAK1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50530394(CHEMBL4561663)
Affinity DataIC50: 400nMAssay Description:Inhibition of JAK1/JAK3 (unknown origin) in IL-2 stimulated cells by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50530394(CHEMBL4561663)
Affinity DataIC50: 0.460nMAssay Description:Inhibition of human recombinant C-terminal Histidine tagged TYK2 JH2 (564 to 876 residues) expressed in Sf9 cells by chromatography methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50530394(CHEMBL4561663)
Affinity DataIC50: 89nMAssay Description:Inhibition of IL-23 induced STAT3 phosphorylation in human Jurkat cells incubated for 30 mins by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50530394(CHEMBL4561663)
Affinity DataIC50: 24nMAssay Description:Inhibition of JAK2 JH1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50530394(CHEMBL4561663)
Affinity DataIC50: 26nMAssay Description:Inhibition of JAK1 JH1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50530394(CHEMBL4561663)
Affinity DataIC50: 15nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50530394(CHEMBL4561663)
Affinity DataIC50: 37nMAssay Description:Inhibition of TYK2 JH2 in human KIT225 cells assessed as reduction of IFNalpha induced STAT1 phosphorylation by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50530394(CHEMBL4561663)
Affinity DataIC50: 180nMAssay Description:Inhibition of IL-23 induced STAT3 phosphorylation in human KIT225 cells by AlphaLISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50530394(CHEMBL4561663)
Affinity DataEC50:  6.60nMAssay Description:Inhibition of TYK2 JH2 (unknown origin) by Scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50530394(CHEMBL4561663)
Affinity DataIC50: 24nMAssay Description:Inhibition of JAK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1/JAK2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50530394(CHEMBL4561663)
Affinity DataIC50: 210nMAssay Description:Inhibition of JAK1/JAK2 (unknown origin) in GM-CSF stimulated cells by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530394(CHEMBL4561663)
Affinity DataIC50: 37nMAssay Description:Inhibition of TYK2/JAK1 in IFNalpha-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1/JAK2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50530394(CHEMBL4561663)
Affinity DataIC50: 210nMAssay Description:Inhibition of JAK1/JAK2 (unknown origin) in GM-CSF stimulated cells by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50530394(CHEMBL4561663)
Affinity DataIC50: 26nMAssay Description:Inhibition of JAK1 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530394(CHEMBL4561663)
Affinity DataIC50: 37nMAssay Description:Inhibition of TYK2/JAK1 in IFNalpha-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530394(CHEMBL4561663)
Affinity DataIC50: 89nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50530394(CHEMBL4561663)
Affinity DataIC50: 24nMAssay Description:Inhibition of JAK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50530394(CHEMBL4561663)
Affinity DataIC50: 26nMAssay Description:Inhibition of JAK1 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50530394(CHEMBL4561663)
Affinity DataIC50: 15nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50530394(CHEMBL4561663)
Affinity DataIC50: 0.460nMAssay Description:Inhibition of fluorescein-labeled kinase tracer binding to His-TVMV-fused TYK2 JH2 domain (575 to 869 residues) (unknown origin) measured after 90 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50530394(CHEMBL4561663)
Affinity DataEC50:  6.60nMAssay Description:Inhibition of TYK2 JH2 (unknown origin) by Scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50530394(CHEMBL4561663)
Affinity DataIC50: 0.460nMAssay Description:Inhibition of fluorescein-labeled kinase tracer binding to His-TVMV-fused TYK2 JH2 domain (575 to 869 residues) (unknown origin) measured after 90 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetJAK3/JAK1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50530394(CHEMBL4561663)
Affinity DataIC50: 400nMAssay Description:Inhibition of JAK1/JAK3 (unknown origin) in IL-2 stimulated cells by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
LigandPNGBDBM50530394(CHEMBL4561663)
Affinity DataIC50: 89nMAssay Description:Inhibition of TYK2/JAK2 in IL23-stimulated human Kit225 cells by steady-glo luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50530394(CHEMBL4561663)
Affinity DataIC50: 15nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50530394(CHEMBL4561663)
Affinity DataKi:  0.0600nMAssay Description:Inhibition of TYK2 JH2 (unknown origin) by morrison titration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Yale University

Curated by ChEMBL
LigandPNGBDBM50530394(CHEMBL4561663)
Affinity DataKi:  0.0600nMAssay Description:Inhibition of TYK2 JH2 (unknown origin) by morrison titration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed