BDBM50530325 CHEMBL4458300

SMILES OC(=O)c1ccc(Nc2nc(cs2)-c2cccc(Br)c2)cc1

InChI Key InChIKey=BQIQIDNGQSNUJD-UHFFFAOYSA-N

Data  2 KI  16 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50530325   

TargetCasein kinase II subunit alpha(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50530325(CHEMBL4458300)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of recombinant human GST-tagged CK2alpha in presence of ATP by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50530325(CHEMBL4458300)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of recombinant human GST-tagged CK2alpha K74A mutant in presence of ATP by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50530325(CHEMBL4458300)
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of recombinant human GST-tagged CK2alpha in presence of ATP by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50530325(CHEMBL4458300)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of recombinant human GST-tagged CK2alpha V73A mutant in presence of ATP by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50530325(CHEMBL4458300)
Affinity DataIC50: 7.70E+3nMAssay Description:Inhibition of recombinant human GST-tagged CK2alpha H160A mutant in presence of ATP by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50530325(CHEMBL4458300)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of recombinant human GST-tagged CK2alpha K74A mutant in presence of ATP by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50530325(CHEMBL4458300)
Affinity DataIC50: 7.70E+3nMAssay Description:Inhibition of recombinant human GST-tagged CK2alpha H160A mutant in presence of ATP by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50530325(CHEMBL4458300)
Affinity DataIC50: 1.09E+4nMAssay Description:Inhibition of recombinant human GST-tagged CK2alpha K77A mutant in presence of ATP by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50530325(CHEMBL4458300)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of recombinant human GST-tagged CK2alpha V73A mutant in presence of ATP by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha 3(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50530325(CHEMBL4458300)
Affinity DataEC50:  1.60E+4nMAssay Description:Inhibition of CK2 in human 786-0 cells assessed as decrease in Akt1 phosphorylation at Ser129 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50530325(CHEMBL4458300)
Affinity DataIC50: 1.09E+4nMAssay Description:Inhibition of recombinant human GST-tagged CK2alpha K77A mutant in presence of ATP by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50530325(CHEMBL4458300)
Affinity DataIC50: 4.20E+4nMAssay Description:Inhibition of CK2alpha (unknown origin) assessed as reduction in nucleolin phosphorylation in presence of ATP by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50530325(CHEMBL4458300)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of CK2alpha (unknown origin) assessed as reduction in GST-Six1 phosphorylation in presence of ATP by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50530325(CHEMBL4458300)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of CK2alpha (unknown origin) assessed as reduction in GST-Six1 phosphorylation in presence of ATP by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit beta(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50530325(CHEMBL4458300)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of CK2beta autophosphorylation (unknown origin) in presence of ATP by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50530325(CHEMBL4458300)
Affinity DataIC50: 4.20E+4nMAssay Description:Inhibition of CK2alpha (unknown origin) assessed as reduction in nucleolin phosphorylation in presence of ATP by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha 3(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50530325(CHEMBL4458300)
Affinity DataEC50:  6.00E+3nMAssay Description:Inhibition of CK2 in human 786-0 cells assessed as decrease in alpha-catenin phosphorylation at Ser641 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha 3(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50530325(CHEMBL4458300)
Affinity DataEC50:  1.60E+4nMAssay Description:Inhibition of CK2 in human 786-0 cells assessed as decrease in Akt1 phosphorylation at Ser129 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit beta(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50530325(CHEMBL4458300)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of CK2beta autophosphorylation (unknown origin) in presence of ATP by radiometric kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha 3(Human)
University of Lyon

Curated by ChEMBL
LigandPNGBDBM50530325(CHEMBL4458300)
Affinity DataEC50:  6.00E+3nMAssay Description:Inhibition of CK2 in human 786-0 cells assessed as decrease in alpha-catenin phosphorylation at Ser641 after 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50530325(CHEMBL4458300)
Affinity DataKi:  700nMAssay Description:Mixed-type inhibition of recombinant human GST-tagged CK2alpha in presence of ATP by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
Saarland University

Curated by ChEMBL
LigandPNGBDBM50530325(CHEMBL4458300)
Affinity DataKi:  700nMAssay Description:Mixed-type inhibition of recombinant human GST-tagged CK2alpha in presence of ATP by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed