BDBM50528813 CHEMBL4163879
SMILES CN(C)C\C=C\C(=O)Nc1ccc(cc1)C(=O)N1CCC[C@H](C1)Nc1ncc(Cl)c(n1)-c1c[nH]c2ccccc12
InChI Key InChIKey=RUBYHLPRZRMTJO-UHFFFAOYSA-N
Data 20 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 20 hits for monomerid = 50528813
Affinity DataIC50: 483nMAssay Description:Inhibition of human recombinant CDK12/CyclinK assessed as reduction in substrate phosphorylation using His-c-Myc as substrate preincubated with enzym...More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Peking Union Medical College
Curated by ChEMBL
Peking Union Medical College
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of CDK13/Cyclin K (unknown origin) preincubated for 10 mins followed by substrate and ATP addition measured after 200 mins by ADP-Glo lumi...More data for this Ligand-Target Pair
Affinity DataIC50: 152nMAssay Description:Inhibition of CDK12/Cyclin K (unknown origin) preincubated for 10 mins followed by substrate and ATP addition measured after 200 mins by ADP-Glo lumi...More data for this Ligand-Target Pair
Affinity DataIC50: 1.05E+4nMAssay Description:Inhibition of recombinant human CDK9 expressed in baculovirus infected Insect cell measured after 30 mins by scintillation counter analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 8.50E+3nMAssay Description:Inhibition of recombinant human CDK7 expressed in baculovirus infected Insect cell measured after 30 mins by scintillation counter analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 158nMAssay Description:Inhibition of recombinant human CDK12 expressed in baculovirus infected Insect cell measured after 30 mins by scintillation counter analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 69nMAssay Description:Inhibition of recombinant human CDK13 expressed in baculovirus infected Insect cell measured after 30 mins by scintillation counter analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 452nMAssay Description:Inhibition of CDK7/Cyclin H (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of CDK2/Cyclin A (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 657nMAssay Description:Inhibition of human recombinant CDK13/CyclinK assessed as reduction in substrate phosphorylation using His-c-Myc as substrate preincubated with enzym...More data for this Ligand-Target Pair
Affinity DataIC50: 834nMAssay Description:Competitive irreversible inhibition of CDK9/cyclin T (unknown origin) in presence of Km ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 193nMAssay Description:Inhibition of CDK9/Cyclin T1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 69nMAssay Description:Inhibition of CDK13/human cyclin K expressed in baculovirus-infected insect cells using pol2 CTD-peptide substrate and [gammaP]ATP by scintillation c...More data for this Ligand-Target Pair
Affinity DataIC50: 158nMAssay Description:Inhibition of human CDK12/human cyclin K expressed in baculovirus-infected insect cells using pol2 CTD-peptide substrate and [gammaP]ATP by scintilla...More data for this Ligand-Target Pair
Affinity DataIC50: 158nMAssay Description:Inhibition of CDK7 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 8.50E+3nMAssay Description:Inhibition of CDK12 (unknown origin)More data for this Ligand-Target Pair
TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Human)
Lebanese American University
Curated by ChEMBL
Lebanese American University
Curated by ChEMBL
Affinity DataIC50: 8.50E+3nMAssay Description:Inhibition of CDK7/cyclin H/MNAT1 (unknown origin) pre incubated up to 60 mins followed by substrate and ATP additionMore data for this Ligand-Target Pair
Affinity DataIC50: 69nMAssay Description:Competitive irreversible inhibition of CDK13/cyclinK (unknown origin) in presence of Km ATPMore data for this Ligand-Target Pair
TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Human)
Lebanese American University
Curated by ChEMBL
Lebanese American University
Curated by ChEMBL
Affinity DataIC50: 8.50E+3nMAssay Description:Competitive irreversible inhibition of CDK7/cyclinH/MAT1 (unknown origin) in presence of Km ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 158nMAssay Description:Competitive irreversible inhibition of CDK12/cyclinK (unknown origin) in presence of Km ATPMore data for this Ligand-Target Pair