BDBM50528542 CHEMBL4472004

SMILES CN([C@@H]1Cc2ccc(cc2C1)C(=O)Nc1cc(cc(c1)C(C)(C)C)-n1cnc(C)c1)c1cncnc1

InChI Key InChIKey=CKFSGFBIQDUWKV-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50528542   

TargetNT-3 growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50528542(CHEMBL4472004)
Affinity DataIC50: 159nMAssay Description:Inhibition of His-tagged human TrkC expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetEpithelial discoidin domain-containing receptor 1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50528542(CHEMBL4472004)
Affinity DataIC50: 14nMAssay Description:Inhibition of GST-tagged recombinant human DDR1 (440 to 876 amino acids) expressed in baculovirus using fluorescein-poly GAT as substrate after 1 hr ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50528542(CHEMBL4472004)
Affinity DataIC50: 174nMAssay Description:Inhibition of His-tagged human TrkA expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetBDNF/NT-3 growth factors receptor(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50528542(CHEMBL4472004)
Affinity DataIC50: 271nMAssay Description:Inhibition of His-tagged human TrkB expressed in baculovirus expression system using Tyr1 peptide as substrate after 1.5 hrs by FRET-based Z-LYTE ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetDiscoidin domain-containing receptor 2(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50528542(CHEMBL4472004)
Affinity DataIC50: 102nMAssay Description:Inhibition of GST-tagged recombinant human DDR2 expressed in baculovirus using fluorescein-poly GAT as substrate after 1 hr by FRET-based LanthaScree...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed