BDBM50528415 CHEMBL4457064

SMILES Cn1ncc(Cl)c1-c1cc(oc1Cl)C(=O)N[C@@H]1CNCC[C@H]1c1ccc(F)c(F)c1

InChI Key InChIKey=PWVOEHRYNRDIPZ-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50528415   

TargetRAC-alpha serine/threonine-protein kinase(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50528415(CHEMBL4457064)
Affinity DataIC50: 3nMAssay Description:Inhibition of human Akt1 expressed in Escherichia coli using STK Substrate 2-biotin as substrate incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase alpha-1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50528415(CHEMBL4457064)
Affinity DataIC50: 48nMAssay Description:Inhibition of RSK1 (unknown origin) by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
LigandPNGBDBM50528415(CHEMBL4457064)
Affinity DataIC50: 156nMAssay Description:Inhibition of PKC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50528415(CHEMBL4457064)
Affinity DataIC50: 0.640nMAssay Description:Inhibition of human Akt2 by mobile shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetRAC-gamma serine/threonine-protein kinase(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50528415(CHEMBL4457064)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of Akt3 (unknown origin) by mobile shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetRAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50528415(CHEMBL4457064)
Affinity DataIC50: 21nMAssay Description:Inhibition of Akt in human LNCaP cells assessed as reduction in PRAS40 phosphorylation at T246 residue after 1 hr by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Sgk1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50528415(CHEMBL4457064)
Affinity DataIC50: 59nMAssay Description:Inhibition of human SGK by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetRibosomal protein S6 kinase beta-1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50528415(CHEMBL4457064)
Affinity DataIC50: 7nMAssay Description:Inhibition of human P70S6K by mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50528415(CHEMBL4457064)
Affinity DataIC50: 20nMAssay Description:Inhibition of human ROCK1 by mobile shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed