BDBM50527819 CHEMBL4557050::US11117865, Compound ZL0516

SMILES Cc1cc(cc(c1OC[C@@H](CN2CCN(CC2)C)O)C)C3=CC(=O)c4c(cc(cc4OC)OC)O3

InChI Key InChIKey=UDPXIEUTIPNLKC-UHFFFAOYSA-N

Data  23 IC50  9 Kd

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 50527819   

TargetBromodomain testis-specific protein [22-138](Human)
University Of Texas

US Patent
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataIC50: 3.59E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataIC50: 720nMAssay Description:Binding affinity to BRD4 BD2 (unknown origin) by fluorescence anisotropy methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataIC50: 8.22E+3nMAssay Description:Binding affinity to BRD4 BD1 (unknown origin) by fluorescence anisotropy methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4 [342-460](Human)
University Of Texas

US Patent
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataIC50: 718nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [49-170](Human)
University Of Texas

US Patent
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataIC50: 84nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetCREB-binding protein(Human)
University Of Texas

US Patent
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataIC50: 1.00E+4nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent

TargetBromodomain testis-specific protein [287-359](Human)
University Of Texas

US Patent
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataIC50: 3.18E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent

TargetBromodomain testis-specific protein [22-138](Human)
University Of Texas

US Patent
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataIC50: 3.59E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 3 [326-398](Human)
University Of Texas

US Patent
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataIC50: 2.50E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 3 [51-123](Human)
University Of Texas

US Patent
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataIC50: 3.12E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetBromodomain-containing protein 2 [364-436](Human)
University Of Texas

US Patent
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataIC50: 914nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 2 [91-163](Human)
University Of Texas

US Patent
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataIC50: 886nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4 [342-460](Human)
University Of Texas

US Patent
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataIC50: 718nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 4 [49-170](Human)
University Of Texas

US Patent
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataIC50: 84nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetCREB-binding protein(Human)
University Of Texas

US Patent
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataIC50: 1.00E+4nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent

TargetBromodomain testis-specific protein [287-359](Human)
University Of Texas

US Patent
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataIC50: 3.18E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 3 [326-398](Human)
University Of Texas

US Patent
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataIC50: 2.50E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 3 [51-123](Human)
University Of Texas

US Patent
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataIC50: 3.12E+3nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetBromodomain-containing protein 2 [364-436](Human)
University Of Texas

US Patent
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataIC50: 914nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent

TargetBromodomain-containing protein 2 [91-163](Human)
University Of Texas

US Patent
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataIC50: 886nMAssay Description:Determine the binding ability of BRD4 compounds to bromodomains of BRD2 and BRD4. 96 well plate based commercial TR-FRET Assay kits (Cayman Chemical,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2022
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetCREB-binding protein(Human)
University Of Texas

US Patent
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataKd: >1.00E+4nMAssay Description:Binding affinity to recombinant CBP (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataKd:  84nMAssay Description:Binding affinity to recombinant BRD4 BD1 (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain testis-specific protein(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataKd:  3.59E+3nMAssay Description:Binding affinity to recombinant BRDT BD1 (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataKd:  886nMAssay Description:Binding affinity to recombinant BRD2 BD1 (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataKd:  718nMAssay Description:Binding affinity to recombinant BRD4 BD2 (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain testis-specific protein(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataKd:  3.18E+3nMAssay Description:Binding affinity to recombinant BRDT BD2 (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataKd:  2.50E+3nMAssay Description:Binding affinity to recombinant BRD3 BD2 (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataKd:  3.12E+3nMAssay Description:Binding affinity to recombinant BRD3 BD1 (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataKd:  914nMAssay Description:Binding affinity to recombinant BRD2 BD2 (unknown origin) incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataIC50: 310nMAssay Description:Inhibition of BRD4 in poly(I:C)-stimulated human SAECs TLR3-inducible IL-6 gene expression pre-incubated for 24 hrs before poly(I:C) stimulation for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBromodomain-containing protein 4(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50527819(CHEMBL4557050 | US11117865, Compound ZL0516)
Affinity DataIC50: 280nMAssay Description:Inhibition of BRD4 in poly(I:C)-stimulated human SAECs TLR3-inducible CIG5 gene expression pre-incubated for 24 hrs before poly(I:C) stimulation for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)