BDBM50526893 CHEMBL4586954

SMILES N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]1CSCc2ccccc2CSC[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)NNC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)CNC1=O

InChI Key InChIKey=PYJOZFZUINVNAW-UHFFFAOYSA-N

Data  3 KI  1 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50526893   

TargetKappa-type opioid receptor(Human)
D'Annunzio University of Chieti���Pescara

Curated by ChEMBL
LigandPNGBDBM50526893(CHEMBL4586954)
Affinity DataEC50:  806nMAssay Description:Agonist activity at human KOR expressed in CHO cell membranes incubated for 1 hr by [35S]-GTPgammaS coupling assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
D'Annunzio University of Chieti���Pescara

Curated by ChEMBL
LigandPNGBDBM50526893(CHEMBL4586954)
Affinity DataIC50: 8.90nMAssay Description:Antagonist activity at human DOR expressed in CHO cell membranes assessed as reduction in SNC80-induced response incubated for 1 hr by [35S]-GTPgamma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
D'Annunzio University of Chieti���Pescara

Curated by ChEMBL
LigandPNGBDBM50526893(CHEMBL4586954)
Affinity DataEC50:  142nMAssay Description:Agonist activity at human DOR expressed in CHO cell membranes incubated for 1 hr by [35S]-GTPgammaS coupling assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
D'Annunzio University of Chieti���Pescara

Curated by ChEMBL
LigandPNGBDBM50526893(CHEMBL4586954)
Affinity DataEC50:  7.5nMAssay Description:Agonist activity at human MOR expressed in CHO cell membranes incubated for 1 hr by [35S]-GTPgammaS coupling assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
D'Annunzio University of Chieti���Pescara

Curated by ChEMBL
LigandPNGBDBM50526893(CHEMBL4586954)
Affinity DataKi:  4.90nMAssay Description:Displacement of [3H]-diprenorphine from human DOR expressed in CHO cell membranes incubated for 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
D'Annunzio University of Chieti���Pescara

Curated by ChEMBL
LigandPNGBDBM50526893(CHEMBL4586954)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]-diprenorphine from human MOR expressed in CHO cell membranes incubated for 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
D'Annunzio University of Chieti���Pescara

Curated by ChEMBL
LigandPNGBDBM50526893(CHEMBL4586954)
Affinity DataKi:  293nMAssay Description:Displacement of [3H]-diprenorphine from human KOR expressed in CHO cell membranes incubated for 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed