BDBM50525343 CHEMBL4440896::US11116757, No. A29

SMILES CCCC(C)N1CCC(CC1)N(Cc1ccccc1NC(=O)C=C)C(=O)Nc1cccc(c1)C(F)(F)F

InChI Key InChIKey=YLLQDHVRMFOGBL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50525343   

TargetDCN1-like protein 1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50525343(CHEMBL4440896 | US11116757, No. A29)
Affinity DataIC50: 60nMAssay Description:Binding affinity to N-terminal GST tagged recombinant human DCN1 (58 to 259 residues) expressed in Escherichia coli BL21(DE3) assessed as reduction i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetDCN1-like protein 1/NEDD8-conjugating enzyme Ubc12(Human)
Memorial Sloan Kettering Cancer Center

US Patent
LigandPNGBDBM50525343(CHEMBL4440896 | US11116757, No. A29)
Affinity DataIC50: 172nMAssay Description:The TR-FRET assay is illustrated in FIG. 3A and FIG. 3B. The TR-FRET assay cocktail was prepared by mixing 50 nM Biotin-DCN1P, 20 nM AlexaFluor488 UB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2022
Entry Details
Go to US Patent

TargetDCN1-like protein 1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50525343(CHEMBL4440896 | US11116757, No. A29)
Affinity DataIC50: 60nMAssay Description:Inhibition of recombinant human His-tagged DCN1 (58 to 259 residues) expressed in Escherichia coli BL21 (DE3) using MIKLFSLKQQKKEEESAGGTK-biotin as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetDCN1-like protein 1(Human)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50525343(CHEMBL4440896 | US11116757, No. A29)
Affinity DataIC50: 58nMAssay Description:Inhibition of GST-tagged DCN1 (unknown origin) using AcUBE2M1-21 incubated for 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed