BDBM50525201 CHEMBL4463124

SMILES CNC[C@@H](O)CN1CCc2c(C1)cccc2OCc1ccc(cc1)-c1nccs1

InChI Key InChIKey=YOIPDYXMOWADRA-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50525201   

TargetHistone-arginine methyltransferase CARM1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50525201(CHEMBL4463124)
Affinity DataIC50: 21nMAssay Description:Inhibition of PRMT4 (unknown origin) using histone H3 (21 to 44 residues) as substrate measured after 60 mins in presence of SAM by AlphaLisa assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 7(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50525201(CHEMBL4463124)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of recombinant full-length human PRMT7 expressed in Sf9 insect cells using Ac-KKDGKKRKRSRKESYK-biotin as substrate measured after 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50525201(CHEMBL4463124)
Affinity DataIC50: 8.60E+3nMAssay Description:Inhibition of PRMT1 (unknown origin) preincubated for 15 mins followed by substrate addition and measured after 60 mins by AlphaLisa assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50525201(CHEMBL4463124)
Affinity DataIC50: 369nMAssay Description:Inhibition of PRMT4 in human MOLM13 cells assessed as reduction in BAF155 dimethylation measured after 96 hrs by Western blotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 8(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50525201(CHEMBL4463124)
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of PRMT8 (unknown origin) preincubated for 15 mins followed by substrate addition and measured after 60 mins by AlphaLisa assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 3(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50525201(CHEMBL4463124)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PRMT3 (unknown origin) preincubated for 15 mins followed by substrate addition and measured after 60 mins by AlphaLisa assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50525201(CHEMBL4463124)
Affinity DataIC50: 545nMAssay Description:Inhibition of PRMT4 in human MOLM13 cells assessed as reduction in PABP1 dimethylation measured after 96 hrs by Western blotting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50525201(CHEMBL4463124)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PRMT5 (unknown origin) preincubated for 15 mins followed by substrate addition and measured after 60 mins by AlphaLisa assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50525201(CHEMBL4463124)
Affinity DataIC50: 7.90E+3nMAssay Description:Inhibition of PRMT6 (unknown origin) preincubated for 15 mins followed by substrate addition and measured after 60 mins by AlphaLisa assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed