BDBM50521731 CHEMBL4450375

SMILES COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc-2c(COc3cc4c5[nH]c(nc5ccc4cc-23)[C@@H]2C[C@H](C)CN2C(=O)[C@@H](NC(=O)OC)C(C)C)c1

InChI Key InChIKey=RYANBKAVEFUKLN-UHFFFAOYSA-N

Data  7 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50521731   

TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521731(CHEMBL4450375)
Affinity DataEC50:  0.0180nMAssay Description:Inhibition of NS5A in HCV genotype 3a S52 infected in human HuH7 transient chimeric replicon cells assessed as reduction in viral replication after 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521731(CHEMBL4450375)
Affinity DataEC50:  0.0110nMAssay Description:Inhibition of NS5A in HCV genotype 4a ED43 infected in human HuH7 transient chimeric replicon cells assessed as reduction in viral replication after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521731(CHEMBL4450375)
Affinity DataEC50:  0.132nMAssay Description:Inhibition of NS5A in HCV genotype 2b MD2b-1 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by lucifer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521731(CHEMBL4450375)
Affinity DataEC50:  0.443nMAssay Description:Inhibition of NS5A L31M mutant in HCV genotype 2a J6 (M31) infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521731(CHEMBL4450375)
Affinity DataEC50:  0.0180nMAssay Description:Inhibition of NS5A in HCV genotype 1b Con1 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521731(CHEMBL4450375)
Affinity DataEC50:  0.00700nMAssay Description:Inhibition of NS5A L31M mutant in HCV genotype 2a JFH1 (M31) infected in human HuH7 replicon cells assessed as reduction in viral replication after 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521731(CHEMBL4450375)
Affinity DataEC50:  0.0110nMAssay Description:Inhibition of NS5A in HCV genotype 1a H77 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed