BDBM50521712 CHEMBL4565239

SMILES COC[C@H]1C[C@H](N(C1)C(=O)[C@@H](NC(=O)OC)C(C)C)c1nc2ccc3cc-4c(OCc5cc(ccc-45)-c4cnc([nH]4)[C@@H]4CCCN4C(=O)[C@@H](NC(=O)OC)C(C)C)cc3c2[nH]1

InChI Key InChIKey=GXDGJFIBYNZDAU-UHFFFAOYSA-N

Data  17 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50521712   

TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521712(CHEMBL4565239)
Affinity DataEC50:  0.0860nMAssay Description:Inhibition of NS5A Y93H mutant in HCV genotype 1b infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by lu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521712(CHEMBL4565239)
Affinity DataEC50:  0.135nMAssay Description:Inhibition of NS5A in HCV genotype 2b MD2b-1 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by lucifer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521712(CHEMBL4565239)
Affinity DataEC50:  10nMAssay Description:Inhibition of NS5A Q30E mutant in HCV genotype 1a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by lu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521712(CHEMBL4565239)
Affinity DataEC50:  0.0370nMAssay Description:Inhibition of NS5A in wild type HCV genotype 1a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521712(CHEMBL4565239)
Affinity DataEC50:  0.00800nMAssay Description:Inhibition of NS5A L31M mutant in HCV genotype 2a JFH1 (M31) infected in human HuH7 replicon cells assessed as reduction in viral replication after 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521712(CHEMBL4565239)
Affinity DataEC50:  0.220nMAssay Description:Inhibition of NS5A Q30R mutant in HCV genotype 1a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by lu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521712(CHEMBL4565239)
Affinity DataEC50:  0.0140nMAssay Description:Inhibition of NS5A in HCV genotype 4a ED43 infected in human HuH7 transient chimeric replicon cells assessed as reduction in viral replication after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521712(CHEMBL4565239)
Affinity DataEC50:  0.0260nMAssay Description:Inhibition of NS5A in HCV genotype 1b Con1 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521712(CHEMBL4565239)
Affinity DataEC50:  0.0210nMAssay Description:Inhibition of NS5A in HCV genotype 1a H77 infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luciferase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521712(CHEMBL4565239)
Affinity DataEC50:  0.280nMAssay Description:Inhibition of NS5A L31M mutant in HCV genotype 2a J6 (M31) infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521712(CHEMBL4565239)
Affinity DataEC50:  0.0260nMAssay Description:Inhibition of NS5A in wild type HCV genotype 1b infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by luci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521712(CHEMBL4565239)
Affinity DataEC50:  4.70nMAssay Description:Inhibition of NS5A Y93H mutant in HCV genotype 1a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by lu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521712(CHEMBL4565239)
Affinity DataEC50:  0.220nMAssay Description:Inhibition of NS5A Y93C mutant in HCV genotype 1a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by lu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521712(CHEMBL4565239)
Affinity DataEC50:  0.370nMAssay Description:Inhibition of NS5A L31M mutant in HCV genotype 1a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by lu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521712(CHEMBL4565239)
Affinity DataEC50:  0.150nMAssay Description:Inhibition of NS5A Q30H mutant in HCV genotype 1a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by lu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521712(CHEMBL4565239)
Affinity DataEC50:  0.190nMAssay Description:Inhibition of NS5A M28T mutant in HCV genotype 1a infected in human HuH7 replicon cells assessed as reduction in viral replication after 3 days by lu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetNonstructural protein 5A(Hepacivirus C)
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50521712(CHEMBL4565239)
Affinity DataEC50:  0.0240nMAssay Description:Inhibition of NS5A in HCV genotype 3a S52 infected in human HuH7 transient chimeric replicon cells assessed as reduction in viral replication after 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed