BDBM50520653 CHEMBL4555209

SMILES Cc1nnc2COCc3c(Cc4ccccc4)c(sc3-n12)C#Cc1cnn(C)c1

InChI Key InChIKey=RPBWYZZANXCAJX-UHFFFAOYSA-N

Data  6 KI  6 IC50  6 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50520653   

TargetBromodomain-containing protein 4(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50520653(CHEMBL4555209)
Affinity DataIC50: 67nMAssay Description:Binding affinity to human BRD4 BD2 (333 to 460 residues) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50520653(CHEMBL4555209)
Affinity DataKd:  94nMAssay Description:Binding affinity to recombinant BRD4 BD2 (unknown origin) assessed as dissociation constant measured for 1200 sec by bio-layer interferometry strepta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50520653(CHEMBL4555209)
Affinity DataKd:  35nMAssay Description:Binding affinity to recombinant BRD4 BD1 (unknown origin) assessed as dissociation constant measured for 1200 sec by bio-layer interferometry strepta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetBromodomain-containing protein 3(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50520653(CHEMBL4555209)
Affinity DataKd:  180nMAssay Description:Binding affinity to recombinant BRD3 BD2 (unknown origin) assessed as dissociation constant measured for 1200 sec by bio-layer interferometry strepta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetBromodomain-containing protein 3(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50520653(CHEMBL4555209)
Affinity DataKd:  73nMAssay Description:Binding affinity to recombinant BRD3 BD1 (unknown origin) assessed as dissociation constant measured for 1200 sec by bio-layer interferometry strepta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetBromodomain-containing protein 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50520653(CHEMBL4555209)
Affinity DataKd:  680nMAssay Description:Binding affinity to recombinant BRD2 BD2 (unknown origin) assessed as dissociation constant measured for 1200 sec by bio-layer interferometry strepta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetBromodomain-containing protein 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50520653(CHEMBL4555209)
Affinity DataKd:  120nMAssay Description:Binding affinity to recombinant BRD2 BD1 (unknown origin) assessed as dissociation constant measured for 1200 sec by bio-layer interferometry strepta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetBromodomain-containing protein 3(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50520653(CHEMBL4555209)
Affinity DataIC50: 16nMAssay Description:Binding affinity to human BRD3 BD1 (24 to 144 residues) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50520653(CHEMBL4555209)
Affinity DataIC50: 35nMAssay Description:Binding affinity to human BRD3 BD2 (306 to 417 residues) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50520653(CHEMBL4555209)
Affinity DataIC50: 41nMAssay Description:Binding affinity to human BRD2 BD2 (349 to 460 residues) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50520653(CHEMBL4555209)
Affinity DataIC50: 3.5nMAssay Description:Binding affinity to human BRD2 BD1 (72 to 205 residues) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50520653(CHEMBL4555209)
Affinity DataIC50: 10nMAssay Description:Binding affinity to human BRD4 BD1 (44 to 168 residues) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50520653(CHEMBL4555209)
Affinity DataKi:  1.70nMAssay Description:Binding affinity to human BRD2 BD1 (72 to 205 residues) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50520653(CHEMBL4555209)
Affinity DataKi:  2.30nMAssay Description:Binding affinity to human BRD4 BD1 (44 to 168 residues) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50520653(CHEMBL4555209)
Affinity DataKi:  2.5nMAssay Description:Binding affinity to human BRD3 BD1 (24 to 144 residues) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 3(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50520653(CHEMBL4555209)
Affinity DataKi:  6.5nMAssay Description:Binding affinity to human BRD3 BD2 (306 to 417 residues) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 2(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50520653(CHEMBL4555209)
Affinity DataKi:  8.5nMAssay Description:Binding affinity to human BRD2 BD2 (349 to 460 residues) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50520653(CHEMBL4555209)
Affinity DataKi:  19nMAssay Description:Binding affinity to human BRD4 BD2 (333 to 460 residues) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed