BDBM50520148 CHEMBL4538751::US10894784, Example 30.03.01.A

SMILES C[C@@H](N1CCN(CC1)C(=O)CC(F)(F)F)c1ccnc(Nc2nc3ccc(cc3[nH]2)-c2cc(C)ncn2)c1

InChI Key InChIKey=HGCJKDOLUCMPFE-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50520148   

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50520148(CHEMBL4538751 | US10894784, Example 30.03.01.A)
Affinity DataIC50: 2.13E+3nMAssay Description:Inhibition of recombinant full length human His-tagged CDK9/CyclinT1 expressed in baculovirus expression system using biotin-labelled Ttds-YISPLKSPYK...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50520148(CHEMBL4538751 | US10894784, Example 30.03.01.A)
Affinity DataIC50: 140nMAssay Description:Inhibition of IKKepsilon/TBK1 in human MDB-MB-231 cells transduced with lentiviral vector expressing human IRF3 assessed as decrease in poly(I:C)-sti...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50520148(CHEMBL4538751 | US10894784, Example 30.03.01.A)
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant full length human N-terminal His-tagged TBK1 using biotin-labelled Ahx-GDEDFSSFAEPG peptide as substrate preincubated with ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50520148(CHEMBL4538751 | US10894784, Example 30.03.01.A)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant full length human C-terminal GST-tagged IKKepsilon expressed in baculovirus expression system using biotin-labelled Ahx-GDE...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50520148(CHEMBL4538751 | US10894784, Example 30.03.01.A)
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged FLT3 (564 to end residues) expressed in sf21 cells using biotin labelled Ahx-GGEEEEYFELVKKKK pe...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50520148(CHEMBL4538751 | US10894784, Example 30.03.01.A)
Affinity DataIC50: 170nMAssay Description:Inhibition of recombinant full length human His6-tagged RSK4 expressed in baculovirus infected sf21 cells using biotin labelled Ahx-KKLNRTLSFAEPG pep...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase ULK1(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50520148(CHEMBL4538751 | US10894784, Example 30.03.01.A)
Affinity DataIC50: 980nMAssay Description:Inhibition of wild-type human partial length ULK1 (M1 to T309 residues) expressed in mammalian expression system by Kinomescan methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50520148(CHEMBL4538751 | US10894784, Example 30.03.01.A)
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant full length human N-terminal His-tagged TBK1 using biotin-labelled Ahx-GDEDFSSFAEPG peptide as substrate preincubated with ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM50520148(CHEMBL4538751 | US10894784, Example 30.03.01.A)
Affinity DataIC50: 18nMAssay Description:Recombinant full-length N-terminally His-tagged human TBK1, expressed in insect cells and purified by Ni-NTA affinity chromatography, was purchased f...More data for this Ligand-Target Pair
In DepthDetails
US Patent