BDBM50520127 CHEMBL4585441::US10844044, Example 87

SMILES Cc1cc(CNC(=O)c2cc(Cn3ccn(C)c3=N)cc(c2)-c2ccc(F)cc2C)ccc1F

InChI Key InChIKey=LEOZOVLOEOWBAL-UHFFFAOYSA-N

Data  1 KI  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50520127   

TargetWD repeat-containing protein 5(Human)
Frederick National Laboratory For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50520127(CHEMBL4585441 | US10844044, Example 87)
Affinity DataKd:  0.0320nMAssay Description:Competitive inhibition of human N-terminal His6-SUMO tagged WDR5 (22 to 334 residues) expressed in Escherichia coli BL21-Gold(DE3) cells using 10-mer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetWD repeat-containing protein 5(Human)
Frederick National Laboratory For Cancer Research

Curated by ChEMBL
LigandPNGBDBM50520127(CHEMBL4585441 | US10844044, Example 87)
Affinity DataKi:  0.800nMAssay Description:A Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay that measures the displacement of the 10mer-Thr-FAM probe in response to compo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
Go to US Patent