BDBM50520040 CHEMBL4438741

SMILES Nc1ncc(cn1)-c1nc2CN(CCc2c(n1)N1CCOCC1)C(=O)c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F

InChI Key InChIKey=CRTCKATZPLYUCW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50520040   

TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50520040(CHEMBL4438741)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of recombinant human PARP1 using histone as substrate after 1 hr in presence of biotinylated NAD+ by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM50520040(CHEMBL4438741)
Affinity DataIC50: 4.80nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate measured after 1 hr by ADP-glo plus luminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50520040(CHEMBL4438741)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of PARP1 (unknown origin) incubated for 1 hr by chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
LigandPNGBDBM50520040(CHEMBL4438741)
Affinity DataIC50: 69nMAssay Description:Inhibition of PI3K-alpha (unknown origin) incubated for 40 mins in presence of ATP by ELISAMore data for this Ligand-Target Pair
In DepthDetails
PubMed