BDBM50519161 CHEMBL4448207

SMILES OC(=O)C[C@H](CN1CC[C@@](F)(CCc2ccc3CCCNc3n2)C1)c1cccc(c1)N1CCOCC1

InChI Key InChIKey=HKDUWRRLEDNORE-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50519161   

TargetIntegrin alpha-V/beta-1(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50519161(CHEMBL4448207)
Affinity DataIC50: 100nMAssay Description:Antagonist activity at integrin alphavbeta1 (unknown origin) expressed in human A549 cells assessed as reduction in cell adhesion to LAP-bi by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-3(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50519161(CHEMBL4448207)
Affinity DataIC50: 126nMAssay Description:Antagonist activity at integrin alphavbeta3 (unknown origin) expressed in human K562 cells assessed as reduction in cell adhesion to LAP-b by fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-8(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50519161(CHEMBL4448207)
Affinity DataIC50: 25nMAssay Description:Antagonist activity at integrin alphavbeta8 (unknown origin) expressed in human K562 cells assessed as reduction in cell adhesion to LAP-b by fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-6(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50519161(CHEMBL4448207)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at integrin alphavbeta6 (unknown origin) expressed in human K562 cells assessed as reduction in cell adhesion to LAP-bi by fluore...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetIntegrin alpha-V/beta-5(Human)
Glaxosmithkline Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50519161(CHEMBL4448207)
Affinity DataIC50: 79nMAssay Description:Antagonist activity at integrin alphavbeta5 (unknown origin) expressed in human K562 cells assessed as reduction in cell adhesion to vitronectin by f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed