BDBM50519047 CHEMBL4521569

SMILES CCNS(=O)(=O)c1cccc(c1)-c1nc(N[C@H](C)C(O)=O)c2c(c(CC)sc2n1)-c1cccc(Oc2ccc(F)cc2)c1

InChI Key InChIKey=FCCICGZGYLPBLZ-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50519047   

TargetApoptosis regulator Bcl-2(Human)
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50519047(CHEMBL4521569)
Affinity DataKi:  1.30E+3nMAssay Description:Displacement of N-terminal fluorescein labelled Puma-BH3 peptide from human N-terminal thrombin cleavage site-fused/His6-tagged Bcl-2 expressed in Es...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50519047(CHEMBL4521569)
Affinity DataKi:  3.90E+4nMAssay Description:Inhibition of Bcl-XL (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50519047(CHEMBL4521569)
Affinity DataKi:  5.00E+4nMAssay Description:Displacement of N-terminal fluorescein labelled Puma-BH3 peptide from TEV-fused His-tagged human Mcl-1 expressed in Escherichia coliBL21(DE3) pLysS c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed