BDBM50519042 CHEMBL4515659

SMILES CCc1sc2ncnc(N[C@H](Cc3ccccc3)C(O)=O)c2c1-c1cccc(Cl)c1C

InChI Key InChIKey=MLKUMODNHNMDBV-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50519042   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50519042(CHEMBL4515659)
Affinity DataKi:  510nMAssay Description:Displacement of N-terminal fluorescein labelled Puma-BH3 peptide from TEV-fused His-tagged human Mcl-1 expressed in Escherichia coliBL21(DE3) pLysS c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50519042(CHEMBL4515659)
Affinity DataKi:  2.90E+4nMAssay Description:Displacement of N-terminal fluorescein labelled Puma-BH3 peptide from human N-terminal thrombin cleavage site-fused/His6-tagged Bcl-2 expressed in Es...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/23/2021
Entry Details Article
PubMed