BDBM50517887 CHEMBL4531563

SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)C\C=C(/F)[C@@H](N)Cc1ccc(O)cc1)C(O)=O

InChI Key InChIKey=ICJHHSVEWAJXJP-UHFFFAOYSA-N

Data  4 KI  4 IC50  10 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50517887   

TargetMu-type opioid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50517887(CHEMBL4531563)
Affinity DataEC50:  60nMAssay Description:Activation of mu opioid receptor (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50517887(CHEMBL4531563)
Affinity DataEC50:  3.20E+4nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHO cells co-expressing beta-arrestin2 assessed as beta-arrestin2 recruitment measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetMu-type opioid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50517887(CHEMBL4531563)
Affinity DataEC50:  3.24E+4nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHO cells co-expressing beta-arrestin2 assessed as beta-arrestin2 recruitment measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetMu-type opioid receptor(Mouse)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50517887(CHEMBL4531563)
Affinity DataIC50: 363nMAssay Description:Agonist activity at FLAG-tagged mouse mu opioid receptor expressed in human HEK293 cells assessed as inhibition of forskolin stimulated cAMP producti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetMu-type opioid receptor(Mouse)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50517887(CHEMBL4531563)
Affinity DataIC50: 398nMAssay Description:Agonist activity at FLAG-tagged mouse mu opioid receptor expressed in human HEK293 cells assessed as inhibition of forskolin stimulated cAMP producti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetDelta-type opioid receptor(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50517887(CHEMBL4531563)
Affinity DataEC50:  764nMAssay Description:Agonist activity at human delta opioid receptor expressed in CHO cells co-expressing beta-arrestin2 assessed as beta-arrestin2 recruitment measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetDelta-type opioid receptor(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50517887(CHEMBL4531563)
Affinity DataEC50:  759nMAssay Description:Agonist activity at human delta opioid receptor expressed in CHO cells co-expressing beta-arrestin2 assessed as beta-arrestin2 recruitment measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetDelta-type opioid receptor(Mouse)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50517887(CHEMBL4531563)
Affinity DataIC50: 34nMAssay Description:Agonist activity at FLAG-tagged mouse delta opioid receptor expressed in human HEK293 cells assessed as inhibition of forskolin stimulated cAMP produ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetDelta-type opioid receptor(Mouse)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50517887(CHEMBL4531563)
Affinity DataIC50: 34nMAssay Description:Agonist activity at FLAG-tagged mouse delta opioid receptor expressed in human HEK293 cells assessed as inhibition of forskolin stimulated cAMP produ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50517887(CHEMBL4531563)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human kappa opioid receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50517887(CHEMBL4531563)
Affinity DataEC50:  60nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50517887(CHEMBL4531563)
Affinity DataEC50:  5nMAssay Description:Agonist activity at human delta opioid receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2022
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50517887(CHEMBL4531563)
Affinity DataEC50:  5nMAssay Description:Activation of delta opioid receptor (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50517887(CHEMBL4531563)
Affinity DataEC50: >1.00E+4nMAssay Description:Activation of kappa opioid receptor (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50517887(CHEMBL4531563)
Affinity DataKi:  26nMAssay Description:Displacement of [3H]DPDPE from human delta opioid receptor expressed in CHO cell membrane measured after 90 mins by liquid scintillation counting met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetDelta-type opioid receptor(Human)
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50517887(CHEMBL4531563)
Affinity DataKi:  26nMAssay Description:Displacement of [3H]DPDPE from human delta opioid receptor expressed in CHO cell membrane measured after 90 mins by liquid scintillation counting met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetMu-type opioid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50517887(CHEMBL4531563)
Affinity DataKi:  43nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cell membrane incubated for 90 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetMu-type opioid receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50517887(CHEMBL4531563)
Affinity DataKi:  43nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cell membrane incubated for 90 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed