BDBM50516930 CHEMBL4448186::US20240115577, Compound 20

SMILES CC#CCn1c(nc2n(C)c(=O)n(Cc3ccc(Cl)cc3C(O)=O)c(=O)c12)N1CCC[C@@H](N)C1

InChI Key InChIKey=RYYJZMGNOUXDPE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50516930   

TargetDipeptidyl peptidase 4(Human)
Guangxi Medical University

Curated by ChEMBL
LigandPNGBDBM50516930(CHEMBL4448186 | US20240115577, Compound 20)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of recombinant human DPP4 expressed in baculovirus infected Sf9 insect cells using Gly-Pro-AMC as substrate preincubated for 15 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetDipeptidyl peptidase 9(Human)
Guangxi Medical University

Curated by ChEMBL
LigandPNGBDBM50516930(CHEMBL4448186 | US20240115577, Compound 20)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of DPP9 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition measured at 60 secs interv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Guangxi Medical University

Curated by ChEMBL
LigandPNGBDBM50516930(CHEMBL4448186 | US20240115577, Compound 20)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of DPP8 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition measured at 60 secs interv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Guangxi Medical University

Curated by ChEMBL
LigandPNGBDBM50516930(CHEMBL4448186 | US20240115577, Compound 20)
Affinity DataIC50: 3.70nMAssay Description:Human DPP4 activity assay data were obtained using a DPP4 Activity Assay Kit (Sigma-Aldrich, MAK088) according to the manufacturer's instructions...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
Go to US Patent