BDBM50516918 CHEMBL4446618::US20240115577, Compound 22

SMILES CC#CCn1c(cc(=O)n(Cc2cccc(F)c2C(O)=O)c1=O)N1CCC[C@@H](N)C1

InChI Key InChIKey=VNQIDHNDEPDUTF-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50516918   

TargetDipeptidyl peptidase 4(Human)
Guangxi Medical University

Curated by ChEMBL
LigandPNGBDBM50516918(CHEMBL4446618 | US20240115577, Compound 22)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of recombinant human DPP4 expressed in baculovirus infected Sf9 insect cells using Gly-Pro-AMC as substrate preincubated for 15 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetDipeptidyl peptidase 9(Human)
Guangxi Medical University

Curated by ChEMBL
LigandPNGBDBM50516918(CHEMBL4446618 | US20240115577, Compound 22)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of DPP9 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition measured at 60 secs interv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Guangxi Medical University

Curated by ChEMBL
LigandPNGBDBM50516918(CHEMBL4446618 | US20240115577, Compound 22)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of DPP8 (unknown origin) using Gly-Pro-AMC as substrate preincubated for 15 mins followed by substrate addition measured at 60 secs interv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Guangxi Medical University

Curated by ChEMBL
LigandPNGBDBM50516918(CHEMBL4446618 | US20240115577, Compound 22)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of recombinant human DPP4 expressed in baculovirus infected Sf9 insect cells using Gly-Pro-AMC as substrate measured at 60 secs interval f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Guangxi Medical University

Curated by ChEMBL
LigandPNGBDBM50516918(CHEMBL4446618 | US20240115577, Compound 22)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant full-length human N-terminal GST-tagged DPP8 expressed in Sf9 insect cells using Gly-Pro-AMC as substrate measured at 60 se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetDipeptidyl peptidase 9(Human)
Guangxi Medical University

Curated by ChEMBL
LigandPNGBDBM50516918(CHEMBL4446618 | US20240115577, Compound 22)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant full-length human N-terminal GST-tagged DPP9 expressed in Sf9 insect cells using Gly-Pro-AMC as substrate measured at 60 se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetDipeptidyl peptidase 9(Human)
Guangxi Medical University

Curated by ChEMBL
LigandPNGBDBM50516918(CHEMBL4446618 | US20240115577, Compound 22)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant full-length human N-terminal GST-tagged DPP9 expressed in Sf9 insect cells using Gly-Pro-AMC as substrate measured at 60 se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Guangxi Medical University

Curated by ChEMBL
LigandPNGBDBM50516918(CHEMBL4446618 | US20240115577, Compound 22)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant full-length human N-terminal GST-tagged DPP8 expressed in Sf9 insect cells using Gly-Pro-AMC as substrate measured at 60 se...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Guangxi Medical University

Curated by ChEMBL
LigandPNGBDBM50516918(CHEMBL4446618 | US20240115577, Compound 22)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of recombinant human DPP4 expressed in baculovirus infected Sf9 insect cells using Gly-Pro-AMC as substrate measured at 60 secs interval f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2021
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Guangxi Medical University

Curated by ChEMBL
LigandPNGBDBM50516918(CHEMBL4446618 | US20240115577, Compound 22)
Affinity DataIC50: 3nMAssay Description:Human DPP4 activity assay data were obtained using a DPP4 Activity Assay Kit (Sigma-Aldrich, MAK088) according to the manufacturer's instructions...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2024
Entry Details
Go to US Patent

TargetDipeptidyl peptidase 4(Human)
Guangxi Medical University

Curated by ChEMBL
LigandPNGBDBM50516918(CHEMBL4446618 | US20240115577, Compound 22)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human recombinant DPP-4More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 8(Human)
Guangxi Medical University

Curated by ChEMBL
LigandPNGBDBM50516918(CHEMBL4446618 | US20240115577, Compound 22)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant DPP-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetDipeptidyl peptidase 9(Human)
Guangxi Medical University

Curated by ChEMBL
LigandPNGBDBM50516918(CHEMBL4446618 | US20240115577, Compound 22)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant DPP-9More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed