BDBM50516108 CHEMBL4556101

SMILES COc1ccc(NC(=O)C2CCN(C(C)C2)c2ncccc2Br)cc1Cl

InChI Key InChIKey=HZCJWMYCYMDXPI-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50516108   

TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50516108(CHEMBL4556101)
Affinity DataIC50: 20nMAssay Description:Inhibition of MALT1-mediated T cell activation in human Jurkat cells assessed in decrease in PMA/ionomycin-induced IL2 productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50516108(CHEMBL4556101)
Affinity DataIC50: 210nMAssay Description:Inhibition of strep-tagged and His-tagged full length MALT1 protease E397A mutant (1 to 824 residues) (unknown origin) expressed in baculovirus infec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50516108(CHEMBL4556101)
Affinity DataIC50: 250nMAssay Description:Inhibition of MALT1 protease in human TMD8 cells assessed as reduction in IL6 level incubated for 24 hrs by mesoscale assay kit methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50516108(CHEMBL4556101)
Affinity DataIC50: 300nMAssay Description:Inhibition of MALT1 protease in human TMD8 cells assessed as reduction in IL10 level incubated for 24 hrs by mesoscale assay kit methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50516108(CHEMBL4556101)
Affinity DataIC50: 110nMAssay Description:Inhibition of MALT1 in human OCI-LY3 cells assessed as reduction in Rel-b cleavageMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50516108(CHEMBL4556101)
Affinity DataIC50: 50nMAssay Description:Inhibition of strep-tagged and His-tagged full length MALT1 protease (1 to 824 residues) (unknown origin) expressed in baculovirus infected insect ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed