BDBM50515436 CHEMBL4441313

SMILES Oc1c(F)c(F)cc(C(=O)c2ccc(s2)-c2ccccc2NS(=O)(=O)c2ccc(Cl)nc2)c1F

InChI Key InChIKey=ZDKXTKFNOBVVDR-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50515436   

TargetEstradiol 17-beta-dehydrogenase 2(Mouse)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50515436(CHEMBL4441313)
Affinity DataIC50: 46nMAssay Description:Inhibition of mouse liver homogenate 17beta-HSD2 using [3H]-E2 as substrate in presence of NAD+ by radio-HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Human)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50515436(CHEMBL4441313)
Affinity DataIC50: 87nMAssay Description:Inhibition of 17beta-HSD2 in human MDA-MB-231 cells using [3H]-E2 as substrate after 6 hrs by radio-HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetEstradiol 17-beta-dehydrogenase 2(Rat)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50515436(CHEMBL4441313)
Affinity DataIC50: 50nMAssay Description:Inhibition of rat liver homogenate 17beta-HSD2 using [3H]-E2 as substrate in presence of NAD+ by radio-HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetEstradiol 17-beta-dehydrogenase 1(Rat)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50515436(CHEMBL4441313)
Affinity DataIC50: 350nMAssay Description:Inhibition of recombinant rat 17beta-HSD1 expressed in HEK293 cells using [3H]-E1 as substrate in presence of NAD+ by radio-HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Human)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50515436(CHEMBL4441313)
Affinity DataIC50: 8.40nMAssay Description:Inhibition of human placental microsomal fraction 17beta-HSD2 using [3H]-E2 as substrate in presence of NAD+ by radio-HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50515436(CHEMBL4441313)
Affinity DataIC50: 17nMAssay Description:Inhibition of human placental cytosolic fraction 17beta-HSD1 using [3H]-E1 as substrate in presence of NAD+ by radio-HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed