BDBM50515434 CHEMBL4518587

SMILES Oc1c(F)c(F)cc(C(=O)c2ccc(s2)-c2ccccc2NS(=O)(=O)c2ccc(F)cc2)c1F

InChI Key InChIKey=CHVVDDGGNOHSOG-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50515434   

Target17-beta-hydroxysteroid dehydrogenase type 1(Human)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50515434(CHEMBL4518587)
Affinity DataIC50: 46nMAssay Description:Inhibition of human placental cytosolic fraction 17beta-HSD1 using [3H]-E1 as substrate in presence of NAD+ by radio-HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Human)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50515434(CHEMBL4518587)
Affinity DataIC50: 48nMAssay Description:Inhibition of 17beta-HSD2 in human MDA-MB-231 cells using [3H]-E2 as substrate after 6 hrs by radio-HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEstradiol 17-beta-dehydrogenase 2(Rat)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50515434(CHEMBL4518587)
Affinity DataIC50: 10nMAssay Description:Inhibition of rat liver homogenate 17beta-HSD2 using [3H]-E2 as substrate in presence of NAD+ by radio-HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEstradiol 17-beta-dehydrogenase 2(Mouse)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50515434(CHEMBL4518587)
Affinity DataIC50: 22nMAssay Description:Inhibition of mouse liver homogenate 17beta-HSD2 using [3H]-E2 as substrate in presence of NAD+ by radio-HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEstradiol 17-beta-dehydrogenase 1(Rat)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50515434(CHEMBL4518587)
Affinity DataIC50: 9nMAssay Description:Inhibition of recombinant rat 17beta-HSD1 expressed in HEK293 cells using [3H]-E1 as substrate in presence of NAD+ by radio-HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Human)
Elexopharm

Curated by ChEMBL
LigandPNGBDBM50515434(CHEMBL4518587)
Affinity DataIC50: 6.10nMAssay Description:Inhibition of human placental microsomal fraction 17beta-HSD2 using [3H]-E2 as substrate in presence of NAD+ by radio-HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed