BDBM50515065 CHEMBL4470496::US10899764, Example 1

SMILES Fc1cccc2-c3cncn3C(C3CCN(CC3)c3ccccc3)c12

InChI Key InChIKey=DURRNOMJUBJEMB-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50515065   

TargetIndoleamine 2,3-dioxygenase 1(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50515065(CHEMBL4470496 | US10899764, Example 1)
Affinity DataIC50: 87nMAssay Description:Inhibition of human IDO1 expressed in Escherichia coli Rosetta measured after 1 hr by microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50515065(CHEMBL4470496 | US10899764, Example 1)
Affinity DataIC50: 338nMAssay Description:Inhibition of human TDO expressed in Escherichia coli Rosetta measured after 1 hr microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50515065(CHEMBL4470496 | US10899764, Example 1)
Affinity DataIC50: 544nMAssay Description:Inhibition of IDO in human HeLa cells using tryptophan as substrate measured after 48 hrs in presence of INF gamma microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50515065(CHEMBL4470496 | US10899764, Example 1)
Affinity DataIC50: 87.4nMAssay Description:IDO1: For testing, 24 μL of enzyme (IDO1) was diluted 100 times with 50 mM KPB to 2400 μL. The concentration of the enzyme solution was 2.6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
Go to US Patent

TargetTryptophan 2,3-dioxygenase(Human)
Shanghai Hengrui Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50515065(CHEMBL4470496 | US10899764, Example 1)
Affinity DataIC50: 338nMAssay Description:TDO: For testing, 24 μL of enzyme (TDO) was diluted 100 times with 50 mM KPB to 2400 μL. The concentration of the enzyme solution was 2.6 n...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2021
Entry Details
Go to US Patent