BDBM50514856 CHEMBL4465880

SMILES CN1CCc2c(C1)nnn2CC(=O)Nc1ccc(Br)c(c1)S(=O)(=O)N1CC[C@@H](C1)C1CC1

InChI Key InChIKey=QFRIGJQJVRCBFQ-UHFFFAOYSA-N

Data  6 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50514856   

TargetATPase family AAA domain-containing protein 2(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50514856(CHEMBL4465880)
Affinity DataIC50: 2.00E+3nMAssay Description:Displacement of Alexa Fluor 488-labeled ligand from FLAG-6His-Tev-fused ATAD2 (981 to 1121 residue) (unknown origin) measured after 30 mins by TR-FRE...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetTranscription initiation factor TFIID subunit 1(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50514856(CHEMBL4465880)
Affinity DataKd:  63nMAssay Description:Binding affinity to human partial length TAF1 bromodomain 2 (D1521 to D1656 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50514856(CHEMBL4465880)
Affinity DataIC50: 5.01E+3nMAssay Description:Displacement of Alexa Fluor 647-labeled ligand from BRD4 BD2 (unknown origin) measured after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetChromatin remodeling regulator CECR2(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50514856(CHEMBL4465880)
Affinity DataIC50: 40nMAssay Description:Inhibition of BSP-BODIPY binding to Nanoluc-tagged CECR2 (unknown origin) expressed in HEK293 cells measured after 4 to 6 hrs by NanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetChromatin remodeling regulator CECR2(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50514856(CHEMBL4465880)
Affinity DataIC50: 6.30nMAssay Description:Displacement of Alexa Fluor 647-labeled GSK tracer from FLAG-6His-Tev-fused CECR2 (424 to 543 residue) (unknown origin) measured after 15 mins by TR-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50514856(CHEMBL4465880)
Affinity DataIC50: 1.26E+4nMAssay Description:Displacement of Alexa Fluor 647-labeled ligand from BRD4 BD1 Y390A mutant (1 to 477 residue) (unknown origin) measured after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetTranscription initiation factor TFIID subunit 1(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50514856(CHEMBL4465880)
Affinity DataIC50: 794nMAssay Description:Inhibition of TAF1 bromodomain 2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetChromatin remodeling regulator CECR2(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50514856(CHEMBL4465880)
Affinity DataKd:  10nMAssay Description:Binding affinity to human partial length CECR2 (P423 to D543 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetHistone acetyltransferase KAT2A(Human)
University of Strathclyde

Curated by ChEMBL
LigandPNGBDBM50514856(CHEMBL4465880)
Affinity DataKd:  158nMAssay Description:Binding affinity to human partial length GCN5L2 (E726 to K837 residues) expressed in bacterial expression system by BROMOscan assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed