BDBM50514753 CHEMBL4557994

SMILES Brc1c[nH]c(c1)C(=O)NCc1cccc(Cn2cnc3ccccc23)c1

InChI Key InChIKey=AFACNZCWWHVATI-UHFFFAOYSA-N

Data  9 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50514753   

TargetIndoleamine 2,3-dioxygenase 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandPNGBDBM50514753(CHEMBL4557994)
Affinity DataIC50: 16nMAssay Description:Inhibition of IDO1 in IFNgamma-stimulated human A375 cells assessed as reduction in L-Kyn level measured after 48 hrs by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandPNGBDBM50514753(CHEMBL4557994)
Affinity DataKd:  550nMAssay Description:Binding affinity to NT650-NHS fluorophore-labeled recombinant human N-terminal His-tagged IDO1 expressed in Escherichia coli measured after 10 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Mouse)
University of Eastern Piedmont

Curated by ChEMBL
LigandPNGBDBM50514753(CHEMBL4557994)
Affinity DataIC50: 13nMAssay Description:Inhibition of mouse IDO1 transfected in P815 cells assessed as reduction in L-Kyn level measured after 16 hrs by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Mouse)
University of Eastern Piedmont

Curated by ChEMBL
LigandPNGBDBM50514753(CHEMBL4557994)
Affinity DataIC50: 5.46E+3nMAssay Description:Inhibition of mouse TDO transfected in P815 cells assessed as reduction in L-Kyn level measured after 16 hrs by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandPNGBDBM50514753(CHEMBL4557994)
Affinity DataIC50: 21nMAssay Description:Inhibition of IDO1 in IFNgamma-stimulated human MCF7 cells assessed as reduction in L-Kyn level measured after 48 hrs by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandPNGBDBM50514753(CHEMBL4557994)
Affinity DataIC50: 43nMAssay Description:Inhibition of IDO1 in IFNgamma-stimulated human HepG2 cells assessed as reduction in L-Kyn level measured after 48 hrs by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandPNGBDBM50514753(CHEMBL4557994)
Affinity DataIC50: 14nMAssay Description:Inhibition of IDO1 in IFNgamma-stimulated human LXF-289 cells assessed as reduction in L-Kyn level measured after 48 hrs by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandPNGBDBM50514753(CHEMBL4557994)
Affinity DataIC50: 64nMAssay Description:Inhibition of IDO1 in IFNgamma-stimulated human HeLa cells assessed as reduction in L-Kyn level measured after 48 hrs by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandPNGBDBM50514753(CHEMBL4557994)
Affinity DataIC50: 605nMAssay Description:Inhibition of IDO1 in IFNgamma-stimulated human DAN-G cells assessed as reduction in L-Kyn level measured after 48 hrs by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
University of Eastern Piedmont

Curated by ChEMBL
LigandPNGBDBM50514753(CHEMBL4557994)
Affinity DataIC50: 16nMAssay Description:Inhibition of human IDO1 using L-tryptophan as substrate assessed as reduction in N-formyl kynurenine formation by UV-visible spectroscopic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed