BDBM50514402 CHEMBL4535757::US11345701, Compound Amg-510
SMILES CC(C)c1nccc(C)c1-n1c2nc(c(F)cc2c(nc1=O)N1CCN(C[C@@H]1C)C(=O)C=C)-c1c(O)cccc1F
InChI Key InChIKey=NXQKSXLFSAEQCZ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50514402
Affinity DataIC50: 68nMAssay Description:Inhibition of KRAS in human MIAPaca2 cells assessed as decrease in EGF-stimulated ERK1/2 phosphorylation preincubated for 2 hrs followed by EGF stimu...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human N-terminal His-tagged KRAS (2 to 185 residues) expressed in baculovirus infected Sf9 insect cells using GTP as substr...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in p-ERK levelsMore data for this Ligand-Target Pair
Affinity DataIC50: 24.5nMAssay Description:NCI-H358 cells expressing KRAS G12C mutant protein were cultured in RPMI 1640 medium (Gibco) containing 10% fetal bovine serum (Gibco). The NCI-H358 ...More data for this Ligand-Target Pair
Affinity DataIC50: 9.70nMAssay Description:Inhibition of KRAS G12C mutant (unknown origin) assessed as inhibition of SOS1-catalyzed nucleotide exchange measured by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7nMAssay Description:Inhibition of biotinylated Avi-His tagged GDP-bound human KRAS G12C mutant (1 to 166 residues) expressed in Escherichia coli assessed as inhibition o...More data for this Ligand-Target Pair
Affinity DataKi: 1.22E+4nMAssay Description:Binding affinity to KRAS G12C mutant (unknown origin) assessed as inhibition constant incubated for 24 hrs by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataKi: 8.60E+4nMAssay Description:Binding affinity to KRAS (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair