BDBM50514401 CHEMBL4549665

SMILES C[C@H]1CN(CCN1c1nc(=O)n(-c2ccccc2C2CC2)c2nc(c(Cl)cc12)-c1c(O)cccc1F)C(=O)C=C

InChI Key InChIKey=FRSNLUYKWNTJHX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50514401   

TargetGTPase KRas(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50514401(CHEMBL4549665)
Affinity DataIC50: 109nMAssay Description:Inhibition of KRAS in human MIAPaca2 cells assessed as decrease in EGF-stimulated ERK1/2 phosphorylation preincubated for 2 hrs followed by EGF stimu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetGTPase KRas(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50514401(CHEMBL4549665)
Affinity DataIC50: 225nMAssay Description:Inhibition of GDP bound recombinant human His-tagged KRAS G12C/C118A mutant (1 to 169 residues) assessed as reduction in SOS1-mediated GDP/GTP nucleo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed